Detection of inter- and postictal calcitonin gene-related peptide (CGRP) in plasma and tear fluid in patients with active epilepsy.

Recruiting

• Conditions: G40.0; Localization-related (focal)(partial) idiopathic epilepsy and epileptic syndromes with seizures of localized onset

• Registration Number: DRKS00031328
• Lead Sponsor: MU München Campus Großhadern Klinik & Poliklinik für Neurologie

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2023-02-22
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

Patients with known epilepsy
- Age > 18 years,
- Sufficient knowledge of German,
- Presence of written consent.

Exclusion Criteria

- Age < 18,
- Presence of primary headache disorder (other than episodic migraine or episodic tension headache)
- Arterial hypertension,
- Pregnancy,
- Therapy with antibodies to CGRP or its receptor in the past 3 months.
- Severe psychiatric or endocrinologic history,
- Use of triptans/other analgesics within 48h prior to examination.

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Quantification of trigeminal CGRP release in patients with epilepsy by measuring CGRP levels in tear fluid and plasma interictal versus ictal.

Secondary Outcome Measures

Name	Time	Method
Relationship between CGRP levels and epilepsy syndrome and seizure semiology or aura, and registration of ictal headache.