Analgesic Effect of Addition Intravenous Dexamethasone to Bupivacaine for Ultrasound-guided Thoracic Paravertebral Block in Video-assisted Thoracoscopic Surgery: A Randomized Controlled Trial

Phase 2

Completed

• Conditions: Analgesic Efficacy of Intravenous Dexamethasone as an Adjunct to Bupivacaine for Ultrasound-guided Paravertebral Block in Video-assisted Thoracoscopic Surgery; Ultrasound-guided thoracic paravertebral block; Intravenous dexamethasone; Video-assisted thoracoscopic surgery

• Registration Number: TCTR20191010002
• Lead Sponsor: Department of Anesthesiology Faculty of Medicine Ramathibodi Hospital, Mahidol University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2019-10-10
• Study Completion: 2021-03-31
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Elective video-assisted thoracoscopic surgery for lung surgery
American Society of Anesthesiologists Classification 1-3

Exclusion Criteria

Body mass index > 35 kg/m2, pre-existing neuropathy (assessed by history and physical examination), history of previous thoracic surgery, significant thoracic kyphoscoliosis, coagulopathy (platelets < 100,000/mL or INR > 1.4), allergy or contraindicated to medications used in study protocol, suspected newly diagnosed diabetes mellitus on the initial screening (preoperative fasting POC glucose > 126 mg/d), uncontrolled diabetes mellitus (HbA1C > 7%), chronic opioid use, chronic systemic corticosteroid use, active infectious condition and refuse to participate

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Duration of analgesia The first time when patient push IV PCA button The time from the block time to the first analgesic requirement

Secondary Outcome Measures

Name	Time	Method
Intraoperative hypotension Intraoperative period BP < 90/60 mmHg or MAP < 20% from baseline BP,Intraoperative fentanyl consumption Intraoperative period mcg,Pain score at rest and on movement At 6 hours, 12 hours, 24 hours and 48 hours postoperatively From 0 (no pain at all) to 10 (worst imaginable pain) ,Postoperative morphine consumption 48 hour after the operation mg,Patient satisfaction score At 48 hours postoperatively From 0 (worst) to 10 (best) ,Complications At 48 hours postoperatively Yes or No