The Utility of Serum Tryptase in the Diagnosis of Shrimp- Induced Anaphylaxis
- Conditions
- Food (Shrimp) Allergy
- Interventions
- Procedure: shrimp challenge
- Registration Number
- NCT01619605
- Lead Sponsor
- Mahidol University
- Brief Summary
The purpose of this study was to investigate the utility of serum tryptase for the confirmation of shrimp-induced anaphylaxis.
- Detailed Description
The diagnosis of anaphylaxis is based primarily on the clinical history. In some circumstances, inability to confirm the clinical diagnosis such as present with unusual manifestation, or when skin signs are absent likely contributes to underrecognition and undertreatment of the disease.
Currently, products of mast cell activation (histamine and total tryptase) can be measure in clinical laboratories as markers of acute anaphylaxis events, however these tests have clinically relevant limitations.
Therefore, development of laboratory tests with improved sensitivity and specificity that will support the clinical diagnosis of anaphylaxis are needed.
In addition, shrimp is the major cause of seafood anaphylaxis among Thai children.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 39
- a history of shrimp allergy
- severe anaphylactic reaction from seafood
- pregnancy
- underlying diseases such as cardiovascular, hepatobiliary, and renal diseases
- on systemic corticosteroid or β-blocking agents
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Shrim shrimp challenge -
- Primary Outcome Measures
Name Time Method Change of Serum tryptases baseline and 60 minutes after the onset of symptoms
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Pediatric allergy clinic, Faculty of Medicine Siriraj Hospital, Mahidol University
🇹🇭Bangkoknoi, Bangkok, Thailand