Evaluating the effect of celecoxib in comparison with acetaminophen on orthodontic pain management

Not Applicable

Recruiting

• Conditions: Pain after placing the first orthodontic wire.; Encounter for fitting and adjustment of orthodontic device; Z46.4

• Registration Number: IRCT20221109056454N1
• Lead Sponsor: Tehran University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 January 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 70

Inclusion Criteria

The patient's age is between 12 and 30 years
The treatment plan for orthodontic patients should be fixed without tooth extraction.
According to little's irregularity index, they should have a moderate rating.
Orthodontic treatment should start with the lower jaw.

Exclusion Criteria

Taking antibiotics and painkillers before orthodontic treatment
Pregnant and lactating women
Patients with history of allergy to celecoxib or acetaminophen
Patients with a history of gastrointestinal or kidney ulcer and liver or cardiovascular failure
History of drug addiction
Not having written informed consent to participate in the study
Patients with periodontal disease

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Overall pain score. Timepoint: 2 hours after wire placement, 6 hours after that, the first night of wire placement, 24 hours after the start, and finally on the second, third, and seventh day. Method of measurement: The patient's score on the severity of orthodontic pain in the general state with the VAS index.;Pain score in chewing mode. Timepoint: 2 hours after wire placement, 6 hours after that, the first night of wire placement, 24 hours after the start, and finally on the second, third, and seventh day. Method of measurement: Patient's score of orthodontic pain severity in chewing state with VAS index.;Pain score in biting position. Timepoint: 2 hours after wire placement, 6 hours after that, the first night of wire placement, 24 hours after the start, and finally on the second, third, and seventh day. Method of measurement: Patient score of orthodontic pain severity in biting state with VAS index.