Strawberries and Knee Osteoarthritis (OA)
- Conditions
- Osteoarthritis, Knee
- Interventions
- Dietary Supplement: PlaceboDietary Supplement: FDS-Strawberry
- Registration Number
- NCT02518347
- Lead Sponsor
- Oklahoma State University
- Brief Summary
The proposed study aims to examine the hypothesis that strawberry supplementation will lower serum biomarkers of inflammation and improve knee function in patients with symptomatic osteoarthritis (OA).
- Detailed Description
The investigators propose the following two specific aims in a randomized crossover placebo-controlled trial in participants with two or more features of the metabolic syndrome and symptomatic osteoarthritis in this 12-week efficacy study:
Aim 1: To assess the effects of strawberries on biomarkers of inflammation \[serum levels of C-reactive protein: CRP; inflammatory cytokines: interleukin-6: IL-6; interleukin 1β: IL-1β; tumor necrosis factor-alpha: TNFα\] Aim 2: To assess the effects of strawberries on knee function as assessed by overall musculoskeletal examination and pain score (ICOAP, KOOS and HAQ-DI).
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 20
- Clinical diagnosis of knee osteoarthritis
- Must have waist circumference >35 inches for women and >40 inches for men
- Cancer
- Heart disease
- Smoking
- Berry allergy
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Placebo Placebo Powder matched for carbohydrates and fiber in the strawberries FDS-Strawberry FDS-Strawberry Freeze-dried strawberry powder (50g/d)
- Primary Outcome Measures
Name Time Method Pain Scores on the Visual Analog Scale six months Inflammatory Biomarkers in Serum six months
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Oklahoma State University
🇺🇸Stillwater, Oklahoma, United States