Comparing Brain Images Before and After MRI-upgrade - TimFit Upgrade Study

Not Applicable

Completed

• Conditions: Quality Control; Neuroimaging
• Interventions: Device: Magnetic Resonance Imaging

• Registration Number: NCT03531580
• Lead Sponsor: University Ghent

Brief Summary

In the Ghent University, an upgrade of the MRI-scanner used for research from Siemens Trio Tim to Siemens Prisma Fit is planned in the near future. As a change of MRI hard- and software might influence brain images, it is necessary to evaluate the images before and after the upgrade.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2017-11-20
• Study Start: 2017-11-29
• Study First Submitted QC: 2018-05-18
• Study First Posted: 2018-05-21
• Primary Completion: 2018-06-30
• Study Completion: 2018-06-30
• Status Verified: 2021-11
• Last Update Submitted: 2021-11-30
• Last Update Posted: 2021-12-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 6

Inclusion Criteria

• Healthy volunteer

Exclusion Criteria

• Protheses or artificial implants, no magnetic or metal parts in the body
• Being pregnant or breastfeeding
• Having claustrophobia

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Healthy volunteers	Magnetic Resonance Imaging	six healthy volunteers: 3 male (age 20-40; 40-60 and 60+) and 3 female (age 20-40; 40-60 and 60+)

Primary Outcome Measures

Name	Time	Method
Change in arterial transit times before versus after MRI-upgrade	7 months, 4 scan sessions of max 1 hour
Change in effective connectivity using resting state functional MRI before versus after MRI-upgrade	7 months, 4 scan sessions of max 1 hour
Change in white matter diffusion before versus after MRI-upgrade	7 months, 4 scan sessions of max 1 hour
Change in cerebral perfusion (ml/100g/min) using Arterial Spin Labeling before versus after MRI-upgrade	7 months, 4 scan sessions of max 1 hour
Difference in image quality of SWI image before versus after MRI-upgrade	7 months, 4 scan sessions of max 1 hour
Change in grey matter volume before versus after MRI-upgrade	7 months, 4 scan sessions of max 1 hour
Difference in image quality of FLAIR image before versus after MRI-upgrade	7 months, 4 scan sessions of max 1 hour
Change in functional connectivity (fc) using Resting State functional MRI before versus after MRI-upgrade	7 months, 4 scan sessions of max 1 hour

Trial Locations

Locations (1)

Ghent University; 🇧🇪 Ghent, Belgium