The effect of pioglitazone on cognitive decline in older patients with type 2 diabetes mellitus - Pioglitazone and cognitive function in diabetes mellitus

Research group (Tokyo Metropolitan Geriatric Hospital and other 12 hospitals)0 个研究点目标入组 240 人开始时间: 2009年9月8日最近更新: 2023年10月17日

适应症

试验速览

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•1. patients with type 1 diabetes mellitus including slowly progressive IDDM, 2. anti-GAD antibody positive patients, 3. insulin-treated patients, 4. psychiatric patients including dementia and depression and neurodegenerative disease (Parkinson disease). 5. patients with symptomatic stroke, 6. patients with poorly controlled blood pressure (systolic blood pressure >200 mmHg or diastolic blood pressure >120 mmHg), 7. patients with unstable blood pressures or orthostatic hypotension, 8. patinets with alcohol intoxication, 9. patients who had a history of head injury. 10. patients with hypoxia, 11. patinets with chonic renal failure (serum CRE >2.0 mg/dl for men, serum CRE> 1.5 mg/dl), 12. patients with severe liver damage, 13. patients with a history of acure myocardial infarction, 14. patients with history of coronary bypass or coronary angioplasty, 15. patients with histoty of heart failre or BNP>150 pg/ml, patients with a history of pioglitazone or donepezil, 16. patients whom doctors judge to be not suitable for the trial.

发起方

Research group (Tokyo Metropolitan Geriatric Hospital and other 12 hospitals)