Neurological Symptoms and Findings in Individuals Exposed to Indoor Air Pollutants
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 35
- 试验地点
- 1
- 主要终点
- [11C]PK11195 binding in the brain
研究概览
简要总结
To evaluate neurological findings with TSPO-PET and MRI in patients who have been exposed to indoor air pollutants and have potentially neurological symptoms.
详细描述
Health problems related to indoor air pollutants have been studied for several decades but there is still not sufficient scientific evidence to prove the association between many of the described symptoms and exposure to mold and other air pollutants.
This research aims on studying the activation of microglia and inflammation in the brains of individuals exposed to indoor air pollutants having neurological symptoms with MRI and TSPO-PET imaging, questionnaires and biomarkers and compare the findings to individuals having neurological conditions without exposure to indoor air pollutants as well as healthy controls.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Signing the informed consent form
- •Adults over 18 years of age
- •Indoor air pollutant groups:
- •Exposed to indoor air pollutants
- •Neurological symptoms
- •Neurological symptoms groups:
- •Neurological symptoms possibly due to adverse external exposure
- •Healthy controls:
- •Reported healthy person
排除标准
- •Pregnancy or breast-feeding
- •Corticosteroid treatment within 4 weeks of imaging
- •Patients with claustrophobia, or a history of moderate to severe anxiety disorder or panic attacks (which could potentially lead to preterm termination of the imaging)
- •Contraindication to PET scan and MRI investigations
- •Exposure to experimental radiation in the past 12 months such that radiodosimetry limits would be exceeded by participating in this study.
- •Intolerance to previous PET scans; i.e. previous hypersensitivity reactions to any PET ligand or imaging agent or failure to participate in and comply with previous PET scans.
- •Neurological symptoms groups and healthy controls:
- •Exposure to indoor air pollutants
结局指标
主要结局
[11C]PK11195 binding in the brain
时间窗: Baseline
Change in microglial activity in the brains of the individuals in different study groups as measured by \[11C\]PK11195 PET imaging
次要结局
- Results from questionnaires(Baseline)
- Neurography measures(Baseline)
- Electromyography measures(Baseline)
- Cerebrospinal fluid biomarkers(Baseline)
- DTI-MRI metrics(Baseline)
- Blood biomarkers(Baseline)