The Predictive and Diagnostic Value of Using Cystatin C and High Sensitive Troponin Level Together for Diagnosis of ACS in Patients With Chronic Kidney Disease Coming to Emergency Department With Chest Pain
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 172
- 试验地点
- 1
- 主要终点
- exclusion of acs
研究概览
简要总结
Our study is planning to evaluate patients with chronic kidney disease who come to the emergency department with chest pain. Estimated GFR (cisGFR) with cystatin and estimated GFR (creaGFR) with creatinine will be calculated. Symptoms, ECG and troponin values of patients will be evaluated for diagnosis of acute coronary syndrome
详细描述
Our study is planning to evaluate patients with chronic kidney disease who come to the emergency department with chest pain. Estimated GFR (cisGFR) with cystatin and estimated GFR (creaGFR) with creatinine will be calculated. Symptoms, ECG and troponin values of patients will be evaluated for diagnosis of acute coronary syndrome and the final diagnosis of AMI will be adjudicated by 2 independent cardiologists.Serial troponin measurements and eGFR values will be proportioned. These values the will be evaluated and compared for patients with acute coronary syndrome(culprit lesion on conventional coronary angiography) and non-ACS ones . With these data we aim to facilitate the diagnosis of acute coronary syndrome,increase the specificity and sensitivity of cardiac troponins for the diagnosis of acute coronary syndrome of patients with chronic kidney disease, increase the utility of high sensitive troponins for patients with chronic kidney disease. Again, with these data, it is aimed to reduce the number of false negative and false positive diagnosis of acute coronary syndrome .
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age over 18,
- •chronic kidney diease having chest pain or equivalent of chest pain (dyspnea, diaphoresis, syncope, nausea, vomiting) -
排除标准
- •age less than 18,
- •missing data,
- •patients referred to or accepted from another medical facility
结局指标
主要结局
exclusion of acs
时间窗: time passed during emergency department visit until discharge avarage of 3-6 hours
exclusion of ACS according to current guidelines
anticipated ACS
时间窗: time passed until PCI (percutaneous coronary intervention) (pre-intervention) or admission to hospital
The role of cystatin C in diagnosis acute coronary syndrome when used with troponin in patients with chronic renal failure.
次要结局
未报告次要终点
研究者
Bedriye Muge Sonmez
associate professor
Ankara Diskapi Training and Research Hospital