A prospective randomised study to assess whether prophylactic atropine administration attenuates the negative haemodynamic effects of induction of anaesthesia with propofol and fentanyl.
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Atropine attenuates the fall in BP HR and MAP during induction of anaesthesia with propofol and fentanyl
研究概览
简要总结
Aim
To study the effect of atropine in suppressing the negative haemodynamic effects of induction agents with propofol and fentanyl during general anaesthesia
Materials and methodology
patients posted for elective surgery are selected
divided into two groups
group A receiving atropine 0.6mg/ml 1cc
group S receiving saline 1cc
Intervention
All patients will be kept on NPO status for 8 hrs before surgery
Patients will be randomized into two groups using closed envelope technique
On arrival to operation theatre ECG NIBP SPO2 will be connected
IV line with 18G cannula will be secured in any of the preipheral veins of upper limbs
Infusion of 500 ml crystalloid will be completed before induction of anaesthesia
Pateints will be premedicated with inj.midaz 1mg
Patients will be preoxygenated with 3 litres of o2 through face mask
Atropine or saline will be given according to the group assigned
Patients will be induce with Propofol 100mg and fentanyl 100mcg
Patients will be ventilated at a tidal volume of 8ml/kg with 4 litres o2 for 5 mins after administration of atracurium 0.5mg/kg
Then patients will be intubated with appropriate size cuffed ET tube
Baseline BP HR MAP will be recorded
All the above will be monitored every minute till 15 mins after induction.
研究设计
- 研究类型
- Interventional
- 分配方式
- Coin toss, Lottery, toss of dice, shuffling cards etc
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •1 Patients posted for elective surgery 2 ASA I and II.
排除标准
- •1 ASA III and IV 2 Patients with contraindications of atropine 3 Patients with IHD/CAD/DIABETIC NEUROPATHY 4 Patients with ECG showing tachyarrythmias 5 Emergency surgeries 6 Mallampatti grade III and IV 7 BMI>35 8 Anticipated difficult airway.
结局指标
主要结局
Atropine attenuates the fall in BP HR and MAP during induction of anaesthesia with propofol and fentanyl
时间窗: Starting point Time of induction with propofol and fentanyl | End point Monitored every minute till 15 mins after induction of anaesthesia
次要结局
未报告次要终点