effects of atropine in suppressing negative haemodynamic effects

Not yet recruiting

Conditions: patients undergoing surgery under general anaesthesia

Registration Number: CTRI/2018/01/011470

Lead Sponsor: Head of the department

Brief Summary: Aim

To study the effect of atropine in suppressing the negative haemodynamic effects of induction agents with propofol and fentanyl during general anaesthesia

Materials and methodology

patients posted for elective surgery are selected

divided into two groups

group A receiving atropine 0.6mg/ml 1cc

group S receiving saline 1cc

Intervention

All patients will be kept on NPO status for 8 hrs before surgery

Patients will be randomized into two groups using closed envelope technique

On arrival to operation theatre ECG NIBP SPO2 will be connected

IV line with 18G cannula will be secured in any of the preipheral veins of upper limbs

Infusion of 500 ml crystalloid will be completed before induction of anaesthesia

Pateints will be premedicated with inj.midaz 1mg

Patients will be preoxygenated with 3 litres of o2 through face mask

Atropine or saline will be given according to the group assigned

Patients will be induce with Propofol 100mg and fentanyl 100mcg

Patients will be ventilated at a tidal volume of 8ml/kg with 4 litres o2 for 5 mins after administration of atracurium 0.5mg/kg

Then patients will be intubated with appropriate size cuffed ET tube

Baseline BP HR MAP will be recorded

All the above will be monitored every minute till 15 mins after induction.

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 40

Inclusion Criteria

1 Patients posted for elective surgery 2 ASA I and II.

Exclusion Criteria

1 ASA III and IV 2 Patients with contraindications of atropine 3 Patients with IHD/CAD/DIABETIC NEUROPATHY 4 Patients with ECG showing tachyarrythmias 5 Emergency surgeries 6 Mallampatti grade III and IV 7 BMI>35 8 Anticipated difficult airway.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Atropine attenuates the fall in BP HR and MAP during induction of anaesthesia with propofol and fentanyl	Starting point Time of induction with propofol and fentanyl \| End point Monitored every minute till 15 mins after induction of anaesthesia

Secondary Outcome Measures

Name	Time	Method

Trial Locations

Locations (1): Kanyakumari Goverment Medical College Hospital.
🇮🇳
Kanniyakumari, TAMIL NADU, India
Kanyakumari Goverment Medical College Hospital.
🇮🇳Kanniyakumari, TAMIL NADU, India
Dr S Dinesh kumar
Principal investigator
9597858452
dinambbs@gmail.com