The effect of preoperative and postoperative vitamin D medication therapy on postoperative urinary IL18,KIM1levels in modarres hospital CABG patients in 1397 year

Phase 1

Recruiting

• Conditions: Post coronary artery bypass graft surgery acute kidney injury.; Postprocedural (acute) (chronic) kidney failure

• Registration Number: IRCT20180131038578N1
• Lead Sponsor: Shahid Beheshti University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 25 March 2019

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 66

Inclusion Criteria

CABG surgery for the first time.
The patient who had just CABG surgery without another surgery at the same time, like valvular replacement.
CPB usage in the surgery.
Patients with vitamin D level less than 20 ng/ml.

Exclusion Criteria

Taking vitamin D supplements before the study.
ESRD or cr level more than 1.5 mg/dl
Taking nephrotoxic drugs.
Less than 3 days gap between angiography and surgery.

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The renal injury marker urinary level interlukin-18. Timepoint: Before the surgery, in no time after surgery , a day after surgery. Method of measurement: The enzyme-linked immunosorbent assay (ELISA).;The renal injury marker urinary level,kidney injury molecule-1. Timepoint: Before the surgery, in no time after surgery , a day after surgery. Method of measurement: The enzyme-linked immunosorbent assay (ELISA).

Secondary Outcome Measures

Name	Time	Method
Creatinine serum levels . Timepoint: In no time before the surgery, after surgery and the day after surgery. Method of measurement: Laboratory test for creatinine.;Bleeding . Timepoint: In no time , 6 hours , 12 hours after surgery 2. Method of measurement: Collected by chest tube by ML/Hour.;Ventilation . Timepoint: During 12 hours after CABG surgery. Method of measurement: Ventilator for ventilation measuring by per hour.;Packed RBC cell transfusion . Timepoint: During 12 hours after CABG surgery . Method of measurement: packed RBC cell bag for transfusion.