Can Vitamin D reduce heart damage in cardiac surgery
Phase 3
- Conditions
- Condition 1: Vitamin d deficiency. Condition 2: Ischemic hypertrophy heart disease.Vitamin D deficiencyIschemic cardiomyopathy
- Registration Number
- IRCT20180118038423N1
- Lead Sponsor
- Shahid Beheshti University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 66
Inclusion Criteria
patients that have CABG surgery for the first time
patients only with coronary surgery and no valvular surgery
patients that we use cardipulmonary pump during the surgery
patients with vitamin D level less than 30 ng/ml
Exclusion Criteria
Patients who have Renal failure
creatinine higher than 1.5 mg/dl
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Caspase 2 enzyme level. Timepoint: Right after intervention(3 days before surgery)-The day of surgery -Next day after surgery. Method of measurement: Immunohistochemstry.;Caspase 3 enzyme level. Timepoint: Right after intervention(3 days before surgery)-The day of surgery -Next day after surgery. Method of measurement: Immunohistochemistery.;Caspase 7 enzyme level. Timepoint: Right after intervention(3 days before surgery)-The day of surgery -Next day after surgery. Method of measurement: Immunohistochemistery.;IL-10 serum level. Timepoint: Right after intervention(3 days before surgery)-The day of surgery -Next day after surgery. Method of measurement: Blood test.;Insulin growth factor. Timepoint: Right after intervention(3 days before surgery)-The day of surgery -Next day after surgery. Method of measurement: blood test.
- Secondary Outcome Measures
Name Time Method Hemorrhage after surgery. Timepoint: Right after surgery. Method of measurement: Suction.;Blood units usage. Timepoint: During the surgery and after that. Method of measurement: Number of blood units.;How lung we used the ventilator. Timepoint: Since the surgery. Method of measurement: ventilator.;Kidney damage. Timepoint: After surgery. Method of measurement: blood test.