A Single Day of Inactivity on the Systemic Metabolic and Inflammatory Exercise Response
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 6
- 试验地点
- 1
- 主要终点
- Concentration of metabolites within the plasma
研究概览
简要总结
Exercise can reduce the risk of several chronic diseases. However, recent studies have suggested sitting for too long before exercising can decrease exercise benefits. This study will help determine why this may occur.
详细描述
Previous work demonstrated a greater utilization of carbohydrates (CHO) at the end of aerobic exercise with a day of reduced activity (<5,000 steps). Additionally, there are differences in the RNA profile at rest and during exercise in pathways related to inflammation, metabolism, and innate immunity that warrant further research. Together, these data highlight that a single day of reduced activity alters systemic homeostasis that affects the exercise response. Given the potency of exercise to ameliorate risk of cardiovascular disease, more research is needed to find factors to augment the exercise response. Therefore, this study has two goals: 1) Analyze circulating metabolomics, and 2) metabolomics and proteomics in response to exercise after a day of reduced activity.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •• between the ages of 18-30 years old
排除标准
- •• free from acute or chronic illness (cardiac, pulmonary, liver, or kidney abnormalities, cancer, uncontrolled hypertension, insulin- or non-insulin dependent diabetes or other known metabolic disorders)
- •do not take medications related to metabolism (i.e., statins, metformin, GLP-1 agonists)
- •free from orthopedic limitations (including any artificial joints)
- •currently smoke or participate in other forms of tobacco use.
研究组 & 干预措施
>8,500 steps the day prior to exericse
干预措施: Decreased step count (Behavioral)
<5,000 steps the day prior to exercise
干预措施: Decreased step count (Behavioral)
结局指标
主要结局
Concentration of metabolites within the plasma
时间窗: Participants will complete the study within 6 weeks of enrollment.
We will collect blood before and immediately after exercise. Plasma will be separated and sent for untargeted metabolomic analysis.
Concentration of proteins within the plasma
时间窗: Participants will complete the study within 6 weeks of enrollment.
We will collect blood before and immediately after exercise. Plasma will be separated and sent for untargeted proteomic analysis.
次要结局
未报告次要终点