Assessment of International Normalized Ratio (INR) Prolongation in Patients Treated Simultaneously With Warfarin and Cephalosporins
Completed
- Conditions
- Pulmonary EmbolismVenous ThrombosisAtrial Fibrillation
- Registration Number
- NCT01857050
- Lead Sponsor
- Meir Medical Center
- Brief Summary
Many drug interactions with Warfarin are well documented in the literature, including interactions with a variety of antibiotics. However,in mamy cases it is difficult to predict when the interaction remains theoretical and when it becomes clinically significant and will be reflected in the individual patient. This study's aim is to identify and characterize related conditions (including comorbidities, laboratory test results and other parameters related to the patient)that might be predictors for drug interactions turning from theoretical to clinically significant.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 236
Inclusion Criteria
- Patients aged 18 and over
- Patients treated with a combination of Warfarin and Cephalosporins
- Patients who were hospitalized in the department of internal medicine
- Patients who were treated with Warfarin without Cefalosporins
Exclusion Criteria
- Patients on Warfarin who did not actually receive the drug during their hospitalization
- Patients whose medical records were not accessible or didn't contain full data
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Reasons for INR prolongation in patients who were treated with the combination of Warfarin and Cephalosporins Participants will be followed for the duration of thei hospital stay, an expected average of 7 days
- Secondary Outcome Measures
Name Time Method