Assessment of INR Prolongation in Patients Treated Simultaneously With Warfarin and Antibiotics From the Cephalosporins Family,Observational Retrospective Study.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 236
- 主要终点
- Reasons for INR prolongation in patients who were treated with the combination of Warfarin and Cephalosporins
研究概览
简要总结
Many drug interactions with Warfarin are well documented in the literature, including interactions with a variety of antibiotics. However,in mamy cases it is difficult to predict when the interaction remains theoretical and when it becomes clinically significant and will be reflected in the individual patient. This study's aim is to identify and characterize related conditions (including comorbidities, laboratory test results and other parameters related to the patient)that might be predictors for drug interactions turning from theoretical to clinically significant.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients aged 18 and over
- •Patients treated with a combination of Warfarin and Cephalosporins
- •Patients who were hospitalized in the department of internal medicine
- •Patients who were treated with Warfarin without Cefalosporins
排除标准
- •Patients on Warfarin who did not actually receive the drug during their hospitalization
- •Patients whose medical records were not accessible or didn't contain full data
结局指标
主要结局
Reasons for INR prolongation in patients who were treated with the combination of Warfarin and Cephalosporins
时间窗: Participants will be followed for the duration of thei hospital stay, an expected average of 7 days
次要结局
未报告次要终点