Examination of the activation of thrombocytes and placental inflammasome in pre-eclampsia
Recruiting
- Conditions
- healthy pregnant womenO14.9Pre-eclampsia, unspecified
- Registration Number
- DRKS00022249
- Lead Sponsor
- niversitätsklinikum Leipzig
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Female
- Target Recruitment
- 66
Inclusion Criteria
Patients with established pre-eclampsia according to national Guidelines and healthy controls with planed cesarean delivery
Exclusion Criteria
acute Inflammation/infection of the mother or fetus, fetal abnormalities, autoimmune diseases of the mother or coronary disease, hypertonia or diabetes outside of the pregnancy, pregnancy associated conditions other than pre-eclampsia (e.g. diabetes, placenta praevia), non-singleton pregnancy.
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method activation of thrombocytes in pripheral blood samples, which are taken before the cesarean and analysed directly. Activation of placental inflammasome in placental biopsies done after the cesarean section with immediate Analysis.
- Secondary Outcome Measures
Name Time Method 1) Correlation between maternal platelet activation and inflammasome associated cytokines in plasma<br>2) Association between placental NLRP3 expression and maternal platelet activation<br>3) Cell specific molecular analysis using scRNA seq