NCT02314455终止不适用
Esophageal Absorption in Eosinophilic Esophagitis
适应症
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 发起方
- Mayo Clinic
- 入组人数
- 14
- 试验地点
- 2
- 主要终点
- Reliability of the d-xylose testing defined by the serum levels
研究概览
简要总结
To determine how the esophagus in active and inactive stages of eosinophilic esophagitis tranmit fluids.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients between the ages of 18 and 80 with eosinophilic esophagitis diagnosed by a combination of compatible symptoms, endoscopic findings, histology, and lack of response to proton pump inhibitors or negative pH study
- •endoscopy with esophageal and duodenal biopsies within two weeks of performance of this study
- •Patients between the ages of 18 and 80 with eosinophilic esophagitis diagnosed by a combination of compatible symptoms, endoscopic findings, histology, and lack of response to proton pump inhibitors or negative pH study, and are now in histologic remission( <15phf) by the use of steroids or the six food elimination diet.
- •Volunteers will be selected for not having any history of esophageal symptoms
排除标准
- •Vulnerable populations, such as those with diminished mental acuity, will be excluded.
- •Patients taking Nsaids within 48 hours of the d-xylose testing
- •artificial sweeteners within 48 hours of the d-xylose testing
- •History of IBD
- •Currently smoking or history of smoking
- •History of Celiac disease
- •Bacterial overgrowth,
- •motility disorders
- •other diffuse small bowel diseases.
结局指标
主要结局
Reliability of the d-xylose testing defined by the serum levels
时间窗: 1 year
D-xylose serum levels will be drawn at 5 and 10 and 60 minutes. D-xylose levels will be compared between the patients with active EOE and healthy controls using the Wilcoxon rank sum test.
次要结局
- D-xylose testing compared to endoscopy/biopsy findings.(1 year)
研究者
David A. Katzka
Principal Investigator
Mayo Clinic
研究点 (2)
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