The Biosensor Using the Target Urine Volatile Organic Compounds for Detecting Diabetic Kidney Disease
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 试验地点
- 1
- 主要终点
- Characteristic of VOCs in DKD
研究概览
简要总结
Volatile organic compounds (VOCs) are easily evaporated substances produced by pathophysiologic metabolism and have been utilized in research as potential new biomarkers for differentiating various diseases, acting as the odor imprints of each disease.
Researchers used metal oxide semiconductors to examine the properties of VOCs produced by diabetic kidney disease patients. Also, the VOCs of those with diabetic kidney disease were then compared with those of healthy individuals and patients with nephrotic syndrome.
The study found that VOCs primarily composed of hydrogen, methanol, and sulfate in diabetic kidney disease patients had a significantly different ability to release free electrons from the metal oxide semiconductors compared to healthy individuals and patients with nephrotic syndrome from other causes. This finding suggested that VOCs could be used as biomarkers which could lead to the replacement of renal biopsy for diagnosis in the future.
详细描述
This study was a descriptive cohort study. General data such as age, gender, medications, other medical conditions, or chronic diseases that might have affected the urine VOCs test were reviewed and recorded from the medical records of subjects who attended the outpatient clinic of the Internal Medicine department at the Suranaree University of Technology Hospital from March 2024 to July 2024. Urine samples from diabetic patients, both with and without abnormal proteinuria, were compared with normal urine samples and urine samples from patients with NS from other causes.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 20 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age > 20 years
- •In DKD and NS groups must undergone renal biopsy before study
排除标准
- •Patients with an estimated glomerular filtration rate (eGFR) < 15 mL/min/1.73 m2
- •Pregnancy
- •Ambiguous pathological results
结局指标
主要结局
Characteristic of VOCs in DKD
时间窗: March 2024- July 2024
Electrical resistance characteristic VOCs by semiconductors in DKD when compared to normal and NS
次要结局
未报告次要终点
研究者
Chatchai Kreepala, MD
Associate Professor Dr. Chatchai Kreepala, M.D.
Suranaree University of Technology