The Biosensor Using the Target Urine VOCs for Detecting DKD Diabetic Kidney Disease
- Conditions
- Urine VOCs From DKD and Nephrotic Syndrome Pateints
- Registration Number
- NCT07137351
- Lead Sponsor
- Suranaree University of Technology
- Brief Summary
Volatile organic compounds (VOCs) are easily evaporated substances produced by pathophysiologic metabolism and have been utilized in research as potential new biomarkers for differentiating various diseases, acting as the odor imprints of each disease.
Researchers used metal oxide semiconductors to examine the properties of VOCs produced by diabetic kidney disease patients. Also, the VOCs of those with diabetic kidney disease were then compared with those of healthy individuals and patients with nephrotic syndrome.
The study found that VOCs primarily composed of hydrogen, methanol, and sulfate in diabetic kidney disease patients had a significantly different ability to release free electrons from the metal oxide semiconductors compared to healthy individuals and patients with nephrotic syndrome from other causes. This finding suggested that VOCs could be used as biomarkers which could lead to the replacement of renal biopsy for diagnosis in the future.
- Detailed Description
This study was a descriptive cohort study. General data such as age, gender, medications, other medical conditions, or chronic diseases that might have affected the urine VOCs test were reviewed and recorded from the medical records of subjects who attended the outpatient clinic of the Internal Medicine department at the Suranaree University of Technology Hospital from March 2024 to July 2024. Urine samples from diabetic patients, both with and without abnormal proteinuria, were compared with normal urine samples and urine samples from patients with NS from other causes.
Recruitment & Eligibility
- Status
- WITHDRAWN
- Sex
- All
- Target Recruitment
- Not specified
- Age > 20 years
- In DKD and NS groups must undergone renal biopsy before study
- Patients with an estimated glomerular filtration rate (eGFR) < 15 mL/min/1.73 m2
- Pregnancy
- Ambiguous pathological results
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Characteristic of VOCs in DKD March 2024- July 2024 Electrical resistance characteristic VOCs by semiconductors in DKD when compared to normal and NS
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Institute of Medicine, Suranaree University of Technology
🇹🇭Nakhon Ratchasima, Thailand
Institute of Medicine, Suranaree University of Technology🇹🇭Nakhon Ratchasima, Thailand