NCT00980707CompletedPhase 4
Utility of Versican and Hyaluronan Measurement in Induced Sputum as Biomarker of Asthma
Associated Scientists to Help Minimize Allergies1 site in 1 country10 target enrollmentStarted: August 2009Last updated:
Conditions
Interventions
Drugs
Trial Snapshot
- Phase
- Phase 4
- Status
- Completed
- Sponsor
- Enrollment
- 10
- Locations
- 1
- Primary Endpoint
- Compare hyaluronan and versican in asthmatics versus atopic non-asthmatics.
Study Overview
Brief Summary
The purpose of this study is to determine the role of versican and hyaluronan measurements in induced sputum as biomarkers of asthma. Enroll 10 subjects with mild persistent asthma who are not receiving treatment with a controller therapy.
Detailed Description
We will compare spirometry, eNO and sputum measurements of versican and hyaluronan before and after treatment with fluticasone 220 ug/bid.
Study Design
- Study Type
- Interventional
- Allocation
- Non Randomized
- Intervention Model
- Single Group
- Primary Purpose
- Diagnostic
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 45 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Allergic asthma defined as a positive methacholine challenge
Exclusion Criteria
- •Non-atopic patients
Arms & Interventions
inhaled corticosteroid
Experimental
All asthmatics will start inhaled corticosteroids.
Intervention: Inhaled corticosteroid (fluticasone) (Drug)
Outcomes
Primary Outcomes
Compare hyaluronan and versican in asthmatics versus atopic non-asthmatics.
Time Frame: 1 year
Secondary Outcomes
No secondary outcomes reported
Investigators
Study Sites (1)
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