A Study Comparing Two Ultrasound-Guided Nerve Block Techniques to Manage Pain After Keyhole Gallbladder Surgery

Phase 1

Not yet recruiting

• Conditions: Pregnancy, childbirth and the puerperium,

• Registration Number: CTRI/2025/04/084379
• Lead Sponsor: Department Of Anaesthesiology Dr Br Ambedkar Medical College And Hospital

Brief Summary

Prospective, double-blinded, interventional trial comparing the analgesic efficacy of two regional anesthesia techniques—Unilateral External Oblique Intercostal Fascial Plane Block (EOIB) and Subcostal Transversus Abdominis Plane Block (TAPB)—in patients undergoing laparoscopic cholecystectomy under general anesthesia.The study aims to evaluate postoperative pain relief by assessing Visual Analogue Scale (VAS) scores at multiple time intervals (0, 6, 12, and 24 hours), the timing of first rescue analgesia, total 24-hour analgesic consumption, patient satisfaction, and any complications. A total of 42 patients will be randomly assigned to either EOIB or TAPB groups, receiving ultrasound-guided nerve blocks with 20 ml of 0.2% Ropivacaine and 4 mg of Dexamethasone post-surgery. The study’s hypothesis suggests that EOIB may provide superior analgesia due to its ability to block both anterior and lateral cutaneous branches of the intercostal nerves. Findings from this research could influence post-laparoscopic cholecystectomy pain management protocols by optimizing regional anesthesia techniques to minimize opioid use and enhance patient recovery.

Detailed Description

Not available

Study Timeline

• Study Start: 2025-04-23
• Last Update Posted: 2025-07-04

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 42

Inclusion Criteria

• Patients posted for laparoscopic cholecystectomy requiring general anesthesia.
• Patients between the ages of 18-65years.
• Patients belonging to American Society of Anesthesiologists physical status (ASA- PS) I, II .

Exclusion Criteria

• Patient with refusal of injection at the site of block.
• Any other additional surgical interventions or conversion to open surgery Patients with drug allergy or history of allergy to amide-type local anesthetics, Patients with a history of narcotic drug use, chronic pain, narcotic substance or alcohol abuse.
• Patients with known severe heart, kidney, liver, life-threatening hematological diseases Patients with psychiatric disorder.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To assess the postoperative analgesic effect of External Oblique Intercostal Fascial Plane Block and Subcostal Transversus Abdominis Plane Block in Laparoscopic Cholecystectomy under general anaesthesia.	Every 2 hours for the first 24 hours post operative period

Secondary Outcome Measures

Name	Time	Method
To assess:	Post operative VAS score at 0,6,12,24 hours

Trial Locations

Locations (1)

Major OT complex; 🇮🇳 Bangalore, KARNATAKA, India

Major OT complex

🇮🇳Bangalore, KARNATAKA, India

Dr Merin Varghese

Principal investigator

08547502337

merinvv@gmail.com