The Relationship Between Arterial Stiffness and Pulmonary and Extrapulmonary Features in Ankylosing Spondylitis

Not yet recruiting

• Conditions: Ankylosing Spondylitis (AS)

• Registration Number: NCT06739369
• Lead Sponsor: Kirsehir Ahi Evran Universitesi

Brief Summary

The aim of this study was to investigate the relationship between arterial stiffness and pulmonary and extrapulmonary features in patients with ankylosing spondylitis.

Detailed Description

Not available

Study Timeline

• Status Verified: 2024-11
• Study First Submitted: 2024-11-27
• Study First Submitted QC: 2024-12-17
• Last Update Submitted: 2024-12-17
• Study First Posted: 2024-12-18
• Last Update Posted: 2024-12-18
• Study Start: 2025-01
• Primary Completion: 2025-09
• Study Completion: 2026-06

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 25

Inclusion Criteria

• Diagnosis of ankylosing spondylitis according to ASAS diagnostic criteria
• Being aged 18-65
• Stable medication use for at least 3 months
• Voluntary participation in the study

Exclusion Criteria

• Having uncontrolled cardiopulmonary disease
• Being pregnant
• Having undergone recent surgery
• Presence of malignancy
• Failure to perform to assessments

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Arterial stiffness	1st day	It will be evaluated with brachial pulse waves.
Respiratory muscle strength	1st day	Maximal inspiratory pressure (MIP) and maximal expiratory pressure (MEP) will be measured using a portable mouth pressure device.
Respiratory muscle endurance	1st day	This will be evaluated with increased workload testing.
Exercise capacity	1st day	Exercise capacity will be assessed with 6 minute walk test.
Peripheral muscle strength	1st day	Hand grip strength will be assessed with a grip dynamometer.
Muscle function	1st day	It will be evaluated with one-minute sit to stand test

Secondary Outcome Measures

Name	Time	Method
Physical activity	1st day	Physical activity level will be evaluated using International Physical Activity Questionnaire-Short form
Forced vital capacity	1st day	Forced vital capacity (FVC) will be assessed using spirometry.
Forced expiratory volume in one second	1st day	Forced expiratory volume in one second (FEV1) will be assessed using spirometry.
Forced expiratory volume in one second/forced vital capacity ratio	1st day	Forced expiratory volume in one second/forced vital capacity ratio will be assessed using spirometry.
Peak expiratory flow	1st day	Peak expiratory flow (PEF) will be assessed using spirometry.
Forced mid-expiratory flow	1st day	Forced mid-expiratory flow (FEF25-75) will be assessed using spirometry.

Trial Locations

Locations (1)

Kirsehir Ahi Evran University; 🇹🇷 Kirsehir, Turkey