Adductor Canal Block and Effect of 10 Versus 30 ml Ropivacaine on Muscle Strength: a Randomized Study in Healthy Volunteers

Phase 4

Completed

• Conditions: Muscle Strength; Healthy Volunteers
• Interventions: Procedure: Adductor canal block with ropivacaine 0.1%

• Registration Number: NCT01981746
• Lead Sponsor: Rigshospitalet, Denmark

Brief Summary

To investigate whether reducing the volume (30 versus 10 ml) ropivacaine injected can reduce the number of subjects with impaired muscle strength following adductor canal block. We hypothesized that adductor canal block with 10 ml 0.1% ropivacaine preserves quadriceps strength compared with an adductor canal block with 30 ml.

Detailed Description

Not available

Study Timeline

• Study Start: 2013-11
• Study First Submitted: 2013-11-05
• Study First Submitted QC: 2013-11-05
• Study First Posted: 2013-11-11
• Primary Completion: 2013-12
• Study Completion: 2013-12
• Status Verified: 2014-01
• Last Update Submitted: 2014-01-09
• Last Update Posted: 2014-01-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 26

Inclusion Criteria

• 18-30 years
• Men
• ASA 1
• Body Mass Index 18-25

Exclusion Criteria

• Allergy to study medication
• Earlier trauma or surgery to the lower limb
• Diabetes Mellitus

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
30 ml	Adductor canal block with ropivacaine 0.1%	30 ml ropivacaine 0.1%, single bolus
10 ml	Adductor canal block with ropivacaine 0.1%	10 ml 0.1% ropivacaine, single bolus

Primary Outcome Measures

Name	Time	Method
Number of subjects with reduced quadriceps strength	0.5 to 6 hours post block	The difference between the two volumes in number of subjects experiencing a reduction in quadriceps muscle strength by more than 25% from baseline in two consecutive assessments.

Secondary Outcome Measures

Name	Time	Method
Quadriceps strength calculated as AUC	30 minutes to 6 hours post block	The difference between the two volumes in maximum voluntary isometric contraction (MVIC) of the quadriceps muscle calculated as "area under the curve" (AUC)
Quadriceps strength in percentage of baseline	2, 3 and 4 hours post block	The difference between the two volumes in maximum voluntary isometric contraction (MVIC) of the quadriceps muscle, assessed as percentage of the baseline value.
Modified 30-second Chair Stand test	2 and 4 hours post block	The difference between the pre block value and the post block value in the modified 30-second Chair Stand test performed on one leg, between the two volumes.
VAS pain scores during warmth stimulation	Mean value for the periode 30 minutes - 6 hours post block	The difference between the two volumes in VAS pain score during warmth stimulation.

Trial Locations

Locations (1)

Department of Anaesthesia, Centre of Head and Orthopaedics, Copenhagen University Hospital, Rigshospitalet; 🇩🇰 Copenhagen, Denmark