The Efficacy of Adductor-Canal-Blockade on Morphine Consumption, Pain and Mobilisation After Total Knee Arthroplasty

Phase 4

Completed

• Conditions: Total Knee Arthroplasty
• Interventions: Procedure: Adductor-Canal-Blockade; Procedure: Adductor-Canal-blockade with saline

• Registration Number: NCT01104883
• Lead Sponsor: Rigshospitalet, Denmark

Brief Summary

The purpose of this study is to determine whether Adductor-Canal-Blockade is effective at reducing morphine consumption and pain, and at the same time improving mobilisation after total knee arthroplasty.

Detailed Description

Not available

Study Timeline

• Status Verified: 2010-04
• Study First Submitted: 2010-04-12
• Study First Submitted QC: 2010-04-14
• Study First Posted: 2010-04-16
• Study Start: 2010-08
• Primary Completion: 2011-03
• Study Completion: 2011-03
• Last Update Submitted: 2011-04-12
• Last Update Posted: 2011-04-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 70

Inclusion Criteria

• Total Knee Arthroplasty in spinal anaesthesia
• ASA 1-3
• BMI 18-40
• Written informed consent

Exclusion Criteria

• Can not cooperate to the exam
• Do not speak or understand Danish
• Drug allergy
• Alcohol or drug abuse
• Daily consumption of strong opioids
• Unable to complete the Timed Up and Go test preoperatively

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Adductor-Canal-Blockade	Adductor-Canal-Blockade	Adductor-Canal-Blockade with ropivacaine
Adductor-Canal-blockade with saline	Adductor-Canal-blockade with saline	Adductor-Canal-blockade with isotonic saline

Primary Outcome Measures

Name	Time	Method
Total morphine consumption	0-24 hours postoperative	Total morphine consumption at the interval 0-24 hours postoperative.

Secondary Outcome Measures

Name	Time	Method
Total morphine consumption	0-26 hours postoperative	Total morphine consumption at the intervals 0-2, 0-4, 0-8 and 0-26 hours postoperative.
Pain during rest	0-26 hours postoperative	0-100 mm at a visual analogue scale (VAS), at the intervals 2, 4, 8, 24 and 26 hours postoperative, and the area under the curve for the intervals 2-24 and 24-26 hours postoperative.
Pain during 45 degrees active flexion of the knee	0-26 hours postoperative	0-100 mm at a visual analogue scale (VAS), at the intervals 2, 4, 8, 24 and 26 hours postoperative, and the area under the curve for the intervals 2-24 and 24-26 hours postoperative.
A change in pain in the placebo group	24-26 hours postoperative	0-100 mm at a visual analogue scale (VAS), at the intervals 24 and 26 hours postoperative.
Postoperative nausea	0-26 hours postoperative	Nausea scores(0-3)at 2,4,8,24,26 hours postoperative.
Zofran consumption	0-26 hours postoperative	Total zofran consumption at the intervals 0-24 and 24-26 hours postoperative.
Sedation	0-26 hours postoperative	Seadtion score (0-3) at 2,4,8,24,26 hours postoperative.
Mobilisation	20-26 hours postoperative	Number of seconds it takes to complete the "Timed Up and Go" test, at 20 and 26 hours postoperative.
Postoperative vomiting	0-26 hours postoperative	Number of vomiting episodes at the intervals 0-2,2-4,4-8,8-24,24-26 hours postoperative.

Trial Locations

Locations (2)

Department of Anaesthesia, Privathospitalet Hamlet, Frederiksberg, Denmark; 🇩🇰 Copenhagen, Frederiksberg, Denmark

Department of Surgery and Anaesthesia, Glostrup Hospital; 🇩🇰 Glostrup, Denmark