Efficacy and Adverse Effects of Curcumin in Patient with Hand Osteoarthritis
Phase 3
- Conditions
- Osteoarthritis hands patients presenting with hand pain, stiffness and impaired hand function at Out-Patient Department, Ramathibodi Hospital.curcumin, hand osteoarthritis, hand stiffness, hand pain, tumeric capsule, hand function
- Registration Number
- TCTR20210929003
- Lead Sponsor
- /A
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- nknown
- Sex
- All
- Target Recruitment
- 74
Inclusion Criteria
1. Patients ages > 50 years
2. Fulfilling the American College of Rheumatology criteria for hand osteoarthritis 1990
3. At least 1 tender joint
4. Joint pain 30 mm according to a visual analog scale (100 mm)
5. No history of fracture or dislocation in hand
6. Accpeted inform consent
Exclusion Criteria
1. History of hand joint surgery
2. Exclude inflammatory joint arthritis
3. Treatment with oral corticosteroids, intra-articular corticosteroids, or hyaluronic acid injection within the previous 3 months
4. On antiplatelet/anticoagulant/chemotherapy
5. Abnormal sensation and motor of upper extremities
6. Abnormal liver function or liver disease
7. Abnormal renal function
8. Allergy to curcumin or NSIADs
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Hand pain at rest At baseline, 4 weeks, 8 weeks, 12 weeks and 24 weeks VAS score -VAS will be graded by patients which zero is completely no hand pain and ten is maximum pain.
- Secondary Outcome Measures
Name Time Method Hand pain at activity At baseline, 4 weeks, 8 weeks, 12 weeks and 24 weeks VAS score -VAS will be graded by patients which zero is completely no hand pain and ten is maximum pain.,Hand morning stiffness at activity At baseline, 4 weeks, 8 weeks, 12 weeks and 24 weeks VAS score -VAS will be graded by patients which zero is completely no hand stiffness and ten is maximum hand stiffness.,Hand grip strength At baseline, 12 weeks and 24 weeks Kg,Pinch strength At baseline, 12 weeks and 24 weeks Kg,Hand function At baseline, 4 weeks, 8 weeks, 12 weeks and 24 weeks DASH,Amount of rescue drug At 4 weeks, 8 weeks, 12 weeks and 24 weeks Number of NSAIDs and Acetaminophen