Evaluation of Adult Onset Still Disease Classification Criteria and Differential Diagnosis at Eighteen Months of Follow-up

Completed

• Conditions: Adult Onset Still Disease

• Registration Number: NCT04750863
• Lead Sponsor: Central Hospital, Nancy, France

Brief Summary

Adult Onset Still Disease (AOSD) is an acquired inflammatory disease of unknown etiology, presenting with non specific symptoms. Its diagnosis rely on sets of criteria, i.e. Fautrel Criteria and Yamaguchi Criteria. However, differential diagnosis might appear during follow-up of patients. The aim of this study is to assess diagnostic performance of Fautral and Yamaguchi Criteria after 18 months of follow-up, and to describe differential diagnosis appearing during follow-up.

Detailed Description

Adult Onset Still Disease (AOSD) is an acquired inflammatory disease of unknown etiology, presenting with non specific symptoms. Other conditions such as cancer, infection or other inflammatory disease might mimick its symptoms. Its diagnosis rely on sets of criteria, i.e. Fautrel Criteria and Yamaguchi Criteria. However, differential diagnosis might appear during follow-up after an initial diagnosis of AOSD. The aim of this study is to assess diagnostic performance of Fautral and Yamaguchi Criteria after 18 months of follow-up, and to describe differential diagnosis appearing during follow-up.

Study Timeline

• Study Start: 2010-07-15
• Status Verified: 2021-02
• Primary Completion: 2021-02-01
• Study Completion: 2021-02-01
• Study First Submitted: 2021-02-08
• Study First Submitted QC: 2021-02-10
• Last Update Submitted: 2021-02-10
• Study First Posted: 2021-02-11
• Last Update Posted: 2021-02-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Not specified
• Target Recruitment: 312

Inclusion Criteria

• adults
• with glycosylated ferritin dosage for suspected adult onset still disease
• with at least 18 month of follow-up

Exclusion Criteria

• known infectious disease
• known cancer
• known active connective tissue disease or vasculitis

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
diagnosis performance of Yamaguchi and Fautrel criteria at 18 months of follow-up	after 18 months of follow-up	Sensitivity, Specificity, positive predictive value, negative predictive value

Secondary Outcome Measures

Name	Time	Method
description of differential diagnosis mimicking adult onset still disease	after 18 months of follow-up
identifying factors associated with the occurence of a differential diagnosis during follow-up	after 18 months of follow-up