Admission of Adult-onset Still Disease Patients in the ICU

Completed

• Conditions: Adult-Onset Still Disease; Critically Ill
• Interventions: Other: data collection

• Registration Number: NCT03276650
• Lead Sponsor: Central Hospital, Nancy, France

Brief Summary

Since its first description in 1971, diagnosing adult-onset Still's disease (AOSD), a rare multisystemic disorder considered as a multigenic autoinflammatory syndrome, remains challenging. Rarely, AOSD may present severe systemic manifestations and require intensive care. The main purpose of the Stil ICU study is to make the first description of the epidemiology of critically ill AOSD patients. The investigators will use a retrospective cohort study design with dual recruitment strategies: (1) via the AOSD referral centres network and (2) via a French academic medical ICU network.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2017-08-25
• Study Start: 2017-09-01
• Study First Submitted QC: 2017-09-07
• Study First Posted: 2017-09-08
• Primary Completion: 2018-06-01
• Study Completion: 2018-08-01
• Status Verified: 2018-09
• Last Update Submitted: 2018-09-19
• Last Update Posted: 2018-09-20

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 45

Inclusion Criteria

• AOSD (history of newly diagnosed)
• ICU admission between January 2001 and June 2017

Exclusion Criteria

• adults under protection
• admission in step-down unit

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
critically ill AOSD patients	data collection	no intervention Data collection from hospitalisation reports (administrative, biological, clinical, outcome)

Primary Outcome Measures

Name	Time	Method
number of patients	At inclusion	Number of patients fulfilling the inclusion criteria

Secondary Outcome Measures

Name	Time	Method
Mortality	through study completion, maximum 17,5 years after admission	Kaplan Meier
Number of rehospitalisation in ICU	through study completion, maximum 17,5 years after admission	need for critical care after the first hospitalisation in ICU
recurrent relapses	through study completion, maximum 17,5 years after admission	number of recurrent flares after the first hospitalisation in ICU
APACHE II	24hour after ICU admission	Acute Physiologic Assessment and Chronic Health Evaluation II
number of hospitalisation in internal medicine ward	through study completion, maximum 17,5 years after admission	number of hospitalisation in internal medicine ward after the first ICU stay

Trial Locations

Locations (1)

CHRU; 🇫🇷 Nancy, France