Exploration of Neuroimaging and Biochemical Prognostic Indicators for Post-operative Cognitive Dysfunction After Coronary Artery Bypass Graft
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Postoperative Cognitive Dysfunction
- Sponsor
- wangqiang
- Enrollment
- 20
- Locations
- 1
- Primary Endpoint
- The brain structure changes
- Last Updated
- 11 years ago
Overview
Brief Summary
Postoperative cognitive dysfunction (POCD) may lead to serious consequences. But the underlying mechanisms are still unclear. Blood Oxygen Level Dependent (BOLD) fMRI and biochemical indicators will be used to explore the underlying mechanisms and represent a promising precursory target for diagnosis and treatment of POCD.
Detailed Description
Postoperative cognitive dysfunction (POCD) is one of the most common complications in patients undergoing cardiac surgery. POCD will not only increase the incidence of complications and mortality, but also influence the quality of life after discharging from the hospital. Many factors are associated with POCD, such as neuroinflammation, age, anesthetics, surgery stress response and genetic factors. But the underlying mechanisms are still unclear. Blood Oxygen Level Dependent (BOLD) fMRI, which could monitor the peripheral neuron spontaneous activity according to the ratio of oxyhemoglobin and deaeration hemoglobin in blood, will be used to investigate whether POCD is induced by the variance in neurons metabolism and spontaneous activity in brain regions. Meanwhile, biochemical indicators will be detected to explore the prompting indicators of POCD. The present study is aimed to represent a promising precursory target for diagnosis and treatment of POCD, and provide novel evidence and insights on the brain changes induced by POCD.
Investigators
wangqiang
Professor
Xijing Hospital
Eligibility Criteria
Inclusion Criteria
- •Aged 18-80 years old
- •Underwent selective CABG surgery
Exclusion Criteria
- •History of central nervous system or psychiatric disorders
- •History of taking sedative, antidepressants, or alcoholism
- •MMSE score less than 23
- •Visual or auditory disorders
- •Educated less than 7 years
- •Claustrophobia
- •Can not be supine
- •Can not tolerate iodinated contrast agents
Outcomes
Primary Outcomes
The brain structure changes
Time Frame: 7 days postoperatively
Using BOLD fMRI to investigate the variance of mean diffusivity and FA in nerve conduction bundle
Secondary Outcomes
- Mini-Mental State Examination(preoperative and 7 days, 3 months and 1 years postoperative)