Risk Identification of Long-term Complications

• Conditions: Severe COVID-19
• Interventions: Other: Pulmonary rehabilitation

• Registration Number: NCT06235866
• Lead Sponsor: Wuhan Central Hospital

Brief Summary

The investigators retrospectively analyze the clinical characteristics of severe COVID-19 in our hospital, and then establish a prediction model for long-term complications in patients with severe COVID-19, and strengthen follow-up to improve the prognosis of patients.

Detailed Description

At present, there is a lack of prediction models for the long-term complications of severe COVID-19. Therefore, the investigators used the hospital big data platform to retrospectively analyze the clinical characteristics of severe COVID-19 in our hospital, and conducted cohort follow-up of the changes in lung function including FEV1, FVC，FEV1% and DLCO, etc and and high-resolution CT of patients after discharge. COX model and other statistical methods were used to establish a prediction model for long-term complications of severe COVID-19, and early identification and intervention, strengthen follow-up, and improve the prognosis of patients.

Study Timeline

• Study Start: 2023-02-01
• Study First Submitted: 2023-10-08
• Study First Submitted QC: 2024-01-29
• Study First Posted: 2024-02-01
• Status Verified: 2024-05
• Last Update Submitted: 2024-05-07
• Last Update Posted: 2024-05-08
• Primary Completion: 2024-09-30
• Study Completion: 2025-11-01

Recruitment & Eligibility

• Status: ENROLLING_BY_INVITATION
• Sex: All
• Target Recruitment: 500

Inclusion Criteria

The patient met the diagnostic criteria for severe COVID-19

Exclusion Criteria

• Pregnant women Patients who died of COVID-19 Patients younger than 18 years of age without pulmonary CT

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Follow-up cohort of patients with severe COVID-19	Pulmonary rehabilitation	The scores of various scales, pulmonary function and imaging changes of patients with severe COVID-19 were collected at 3 months, 6 months and 12 months after rehabilitation and discharge.

Primary Outcome Measures

Name	Time	Method
Lung function	1 year	Pulmonary function indicators improved gradually
Imaging of the lung	1 year	The residual lesions in the lung were gradually absorbed

Trial Locations

Locations (1)

Follow-up of patients with severe COVID-19; 🇨🇳 Wuhan, China