Impact of Bariatric Surgery on Epicardial Adipose Tissue and on Myocardial Function
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 44
- 试验地点
- 2
- 主要终点
- The change in EAT amount 6 months after bariatric surgery.
研究概览
简要总结
Growing evidence suggests that bariatric surgery is a relevant treatment for severely obese patients, especially those with metabolic complications, as it significantly reduces weight, hypertension and ameliorates glycemic control. Its action on adipose tissue distribution and in particular on epicardial adipose tissue EAT remains unknown. Whether metabolic improvement is associated with EAT reduction is also unknown.
The researchers thus investigated the effect of bariatric surgery on EAT in severely obese patients. The primary endpoint of this study was the change in EAT amount 6 months after bariatric surgery.
详细描述
The best of our knowledge, no study has really addressed whether this EAT was modulated by diet or therapeutics like bariatric surgery. The researchers were particularly interested in studying the impact of bariatric surgery and of weight loss on the amount of EAT and whether reduction in EAT could have a positive impact on myocardial function.
研究设计
- 研究类型
- Interventional
- 干预模型
- Crossover
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •men or women who have more than 18 years
- •patients have been informed and have consented
- •severely obese patients with surgery indication
排除标准
- •contraindications at surgery, at MNR imagery
- •History of infarct, of congenital cardiomyopathy
- •Treatment modifying the distribution of the fat
- •Pregnant or breast-feeding women
- •patients less than 18 years
- •Patient without consentment
结局指标
主要结局
The change in EAT amount 6 months after bariatric surgery.
时间窗: 36 months
We thus investigated the effect of bariatric surgery on EAT in severely obese patients.
次要结局
- Evaluation of 3 parameters(36 months)