Investigation of the Effect of Bariatric Surgery on Knee Pain, Disability, Quality of Life and Central Sensitization
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 50
- 主要终点
- numeric rating scale (NRS)
研究概览
简要总结
Nowadays obesity is emerging as a very common health problem. It has been shown in various studies that obesity may be an important risk factor for the onset and progression of knee osteoarthritis (OA). The aim of this study is to determine the effects of bariatric surgery on knee pain, loss of function, quality of life and central sensitization.
详细描述
Weight loss in patients with knee OA reduces pain and provides functional improvement. It has been shown that bariatric surgery combined with diet and exercise changes have positive effects on weight loss, knee pain and function.
Neuropathic pain is a disease that affects the somatosensory system or pain that results in a lesion. It has been reported that neuropathic pain is more frequently seen in patients with high body mass index.
The hyperreactivity of the central nervous system (CNS) plays an important role in the chronic pain of OA patients. It has been shown that CNS becomes hypersensitive in people with chronic OA pain and central sensitization phenomenon plays an important role in pain complaints reported by these patients.
The aim of this study is to determine the effects of bariatric surgery on knee pain, loss of function, quality of life and central sensitization.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients decided to undergo bariatric surgery
- •Patients with knee pain more than 3 months.
排除标准
- •Patients with mental impairment,
- •Patients with inflammatory rheumatic disease,
- •Patients who had previously undergone knee surgery
结局指标
主要结局
numeric rating scale (NRS)
时间窗: 6 months
It is commonly used to measure the severity of the patients' pain. It consists of a line 10 cm. long and marked with numbers from 0 to 10. The patient is asked to mark the point corresponding to the severity of the pain on this line in the range from 0 (no pain) to 10 (most severe pain).
Nottingham Health Profile
时间窗: 6 months
for quality of life
Central Sensitization Inventory (CSI)
时间窗: 6 months
for central sensitization
Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC)
时间窗: 6 months
for function
次要结局
未报告次要终点
研究者
Dr. Burcu Metin Ökmen
Principal Investigator
Bursa Yüksek İhtisas Education and Research Hospital