A Comparative Evaluation Of Efficacy Of Nebulisation With Dexmedetomidine And Nebulisation With 4% Lignocaine Plus Dexmedetomidine For Awake Fibreoptic Intubation In Difficult Airway Scenario: A Randomized Control Trial
Trial Snapshot
- Phase
- Phase 2/3
- Status
- Not yet recruiting
- Enrollment
- 80
- Locations
- 1
- Primary Endpoint
- 1.sedation/alertness(OAA SCORE)
Study Overview
Brief Summary
A COMPARATIVE EVALUATION OF EFFICACY OF NEBULIZATION WITH DEXMEDETOMIDINE AND NEBULIZATION WITH 4% LIGNOCAINE PLUS DEXMEDETOMIDINE FOR AWAKE FIBEROPTIC INTUBATION IN DIFFICULT AIRWAY SCENARIO
Different topical and regional techniques have been developed to subdue reflexes and facilitate awake fiberoptic intubation .It is essential to sufficiently anesthetize the upper airway and suppress the gag, swallow ,and cough reflexes prior to awake fiberoptic intubation and thus ensure patient comfort
PRIMARY OBJECTIVES:
A comparative double blinded randomised study will be performed-
- To evaluate the effect of preoperative nebulisation with dexmedetomidine and preoperative nebulisation with dexmedetomidine plus lignocaine for awake fiberoptic intubation on-
a) sedation/alertness
b) vocal cord /limb movement
c) coughing
Study Design
- Study Type
- Interventional
- Allocation
- Computer generated randomization
- Masking
- Not Applicable
Eligibility Criteria
- Ages
- 20.00 Year(s) to 60.00 Year(s) (—)
- Sex
- All
Inclusion Criteria
- •patient consent, ASA grade 1 and 2, patient with anticipated difficult intubation(LEMON >2), BMI >30 kg/m2.
Exclusion Criteria
- •patient refusal, airway hypersensitivity, allergy to drugs used (lignocaine/dexmedetomidine),epileptic patients,patients with poor cardiopulmonary reserve, bleeding tendency, obesity, other co-morbid conditions.
Outcomes
Primary Outcomes
1.sedation/alertness(OAA SCORE)
Time Frame: 0 to 5 min
2.vocal cord movement(%)
Time Frame: 0 to 5 min
3.limb movement
Time Frame: 0 to 5 min
4.fibreoptic intubation score
Time Frame: 0 to 5 min
5.coughing
Time Frame: 0 to 5 min
Secondary Outcomes
- 1) To compare the hemodynamic changes of two groups(2) Dose sparing effect of propofol)