The outcome of liver infection by hepatitis C virus in kidney failure patients who undergo kidney transplantatio
Not Applicable
- Conditions
- Health Condition 1: null- HEPATITIS C POSITIVE PATIENTS UNDERGOING RENAL TRANSPLANTATIO
- Registration Number
- CTRI/2015/02/005513
- Lead Sponsor
- RABINDRANATH TAGORE INTERNATIONAL INSTITUTE OF CARDIAC SCIENCESKOLKATA
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 60
Inclusion Criteria
1.AGE: No age bar for transplantation.
2.SEX: Both males and females are to be selected for the study.
3.Patients with ESRD having hepatitis C virus infection.
4.Patient or family member must give informed consent.
Exclusion Criteria
1.Patients who are positive for Human Immuno-deficiency virus (HIV) or Hepatitis B virus infection (HBsAg).
2.Informed consent not given by patient or family member.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1.Acute rejection- when <br/ ><br>serum creatinine level increases by more than 30% of basal values. <br/ ><br>2.Graft loss-defined as return of the patient to dialysis or patient death. <br/ ><br>3.Post-operative liver function <br/ ><br>4.HCV RNA-by quantitative polymerase chain reaction (PCR) assays <br/ ><br> <br/ ><br>Timepoint: SERUM CREATININE AT 1, 3, 6, 12 MONTHS <br/ ><br>LIVER FUNCTION TEST AT 1,3 6,12 MONTHS <br/ ><br>LIPID PROFILE AT 1,3, 6,12 MONTHS <br/ ><br>DEATH OR RETURN TO DIALYSIS ANY TIME DURING THE STUDY PERIOD <br/ ><br>
- Secondary Outcome Measures
Name Time Method 1.liver histology post renal transplant. <br/ ><br>2.mortality due to other causes <br/ ><br>3.number of hospital addmission post transplantTimepoint: retrospective 7 years <br/ ><br>prospective 2 years