Development and Validation of a Preoperative Frailty Index Using Health Administrative Data

Completed

• Conditions: Surgery; Predictive Value of Tests; Frail Elderly Syndrome; Outcomes
• Interventions: Diagnostic Test: Frailty index

• Registration Number: NCT03354546
• Lead Sponsor: Ottawa Hospital Research Institute

Brief Summary

The investigators will create a frailty index using health administrative data available for older people having surgery. The index will be based on the Canadian Study of Health and Aging Frailty Index and standard recommendations for creation of frailty indices.

Detailed Description

The investigators will create a frailty index using health administrative data available for older people having surgery. The index will be based on the Canadian Study of Health and Aging Frailty Index and standard recommendations for creation of frailty indices.

Once derived the index will be tested to measure its association with outcomes, as well as its discrimination. Various representations of the frailty index will be tested (primary-as a continuous measure; secondary as a binary, categorical and fractional polynomial variable). Performance in subgroups will also be evaluated,

Study Timeline

• Study Start: 2002-04-01
• Primary Completion: 2016-03-31
• Study Completion: 2016-03-31
• Status Verified: 2017-11
• Study First Submitted: 2017-11-17
• Study First Submitted QC: 2017-11-24
• Last Update Submitted: 2017-11-24
• Study First Posted: 2017-11-28
• Last Update Posted: 2017-11-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 200000

Inclusion Criteria

• Having elective or emergency noncardiac surgery

Exclusion Criteria

• no provincial health insurance number

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Elective noncardiac surgery	Frailty index	Individuals having major noncardiac surgery following an elective hospital admission
Emergency general surgery	Frailty index	Individuals having general surgery following an urgent hospital admission

Primary Outcome Measures

Name	Time	Method
Survival for One Year After Surgery	Date of surgery to 365 days after surgery	Still being alive (no death date) in the registered persons database Outcome is binary, exposure is per 0.1 unit increase

Secondary Outcome Measures

Name	Time	Method
Institutional Discharge	Date of surgery to date of hospital discharge, or up to one year after surgery (whichever comes first)	Discharge to long term care or continuing care facility at the time of hospital discharge