Study of Cognitive-linguistic Profiles in Brain-injured Adults: the Role of Executive Control in Mild Aphasia.
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- measure the proportion of patients with mild post-stroke aphasia exhibiting deficits in linguistic executive control within three months of a first stroke
研究概览
简要总结
In France, stroke affects 150,000 people annually and is the leading cause of acquired disability in adults; 10-12% of patients exhibit mild post-stroke aphasia, a condition defined by language difficulties.
Few studies describe mild post-stroke aphasia, and none characterize the impairment of linguistic executive control in this population; consequently, its prevalence remains unknown. To date, the role of linguistic executive control in mild aphasia remains an open question.
The aim of this project is to investigate linguistic executive control impairment in stroke survivors with mild aphasia, provide an initial estimate of its prevalence, and demonstrate its interactions with other linguistic and communicative aspects, as well as with executive and attentional functions.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient who has experienced a first ischemic stroke resulting in clinical symptoms within the last 3 months and is receiving care in the Physical Medicine and Rehabilitation department.
- •Score ≤ 31 on the conversational speech observation scale of the MEC test (Montreal Protocol for the Evaluation of Communication).
- •Patients with a BDAE score ≥ 3 (Boston Diagnostic Aphasia Examination - French version, Mazaux J.-M. [1990]); this score is the gold standard in aphasiology.
- •Native French-speaking patient capable of understanding oral or written instructions.
排除标准
- •Patients exhibiting behavior or a clinical condition incompatible with test administration, as assessed by the clinician.
- •Known major visual, auditory, or motor impairments incompatible with test performance.
- •Known neurodegenerative and/or neurodevelopmental disorders.
- •Known social cognition disorders (e.g., ASD).
研究组 & 干预措施
Patients whose neuropsychological and speech-language pathology tests will be randomized
干预措施: Neuropsychological tests (Diagnostic Test)
Patients whose neuropsychological and speech-language pathology tests will be randomized
干预措施: Speech-language assessments (Diagnostic Test)
结局指标
主要结局
measure the proportion of patients with mild post-stroke aphasia exhibiting deficits in linguistic executive control within three months of a first stroke
时间窗: 7 days after the inclusion
CATEX score result (deficit score if below the mean value minus 1.65 times the standard deviation)
次要结局
- Identification of patients' cognitive-linguistic impairment profiles based on cognitive test scores(7 days after the inclusion)
- Identification of patients' cognitive-linguistic impairment profiles based on stroke location using factor analysis(7 days after the inclusion)
- Study of the correlation between executive control of language (CATEX score) and the score of the test evaluating access to the lexical stock(7 days after the inclusion)
- Study of the correlation between linguistic executive control (CATEX score) and the score of the test evaluating access to the semantic system(7 days after the inclusion)
- Study of the correlation between linguistic executive control (CATEX score) and the score of the test evaluating non-verbal executive control(7 days after the inclusion)
- Study of the correlation between linguistic executive control (CATEX score) and the score of the test evaluating gnosies(7 days after the inclusion)