Dexmedetomidine Nebulization for Attenuation of Pressor Response to Laryngoscopy and Endotracheal Intubation in Sever Preeclamptic Patients Undergoing Caesarean Section Under General Anaesthesia
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 100
- 主要终点
- Systolic blood pressure in response to endotracheal intubation
研究概览
简要总结
Dexmedetomidine nebulization in sever preeclamptic patients
详细描述
Dexmedetomidine nebulization for attenuation of pressor response to laryngoscopy and endotracheal intubation in sever preeclamptic patients undergoing caesarean section under general anaesthesia. A prospective randomized clinical trial.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Patients with severe pre-eclampsia scheduled for cesarean section under general anesthesia
- •ASA II, III
排除标准
- •sever obesity (BMI ≥ 40)
- •Cardiac patients
- •History of diabetes mellitus
- •Renal dysfunction (elevated serum creatinine > 2mg\dl)
- •hepatic dysfunction (elevated hepatic enzyme three times above normal)
- •History to hypersensitivity to the tested drug.
- •Emergency surgery
- •Known fetal anomalies
研究组 & 干预措施
Dexmedetomidine
Nebulization of dexmedetomidine
干预措施: Dexmedetomidine (Drug)
Saline
Nebulization of saline
干预措施: Saline (Drug)
结局指标
主要结局
Systolic blood pressure in response to endotracheal intubation
时间窗: Intraoperative
the change in systolic blood pressure in response to endotracheal intubation
次要结局
- Optic nerve sheath diameter(Intraoperative)
- Incidence of maternal postoperative sore throat(1 hour Postoperative)
- Incidence of maternal postoperative hoarseness of voice(1 hour Postoperative)
研究者
Mohamed Sayed Hussein Hassan
Dexmedetomidine nebulization for attenuation of pressor response to laryngoscopy and endotracheal intubation in sever preeclamptic patients undergoing caesarean section under general anaesthesia. A prospective randomized clinical trial.
Assiut University