Acute Metabolic and Endocrine Responses of Glucose and Fructose in Healthy Young Subjects

Not Applicable

Completed

• Conditions: Healthy

• Registration Number: NCT02590913
• Lead Sponsor: Zhejiang University

Brief Summary

The purpose of this study is to investigate the metabolic and endocrine responses during 3 hour after taking 75g fructose or glucose in young Chinese.

Detailed Description

The study was a double-blinded, randomized, crossover trial. Twenty healthy volunteers were randomized to two groups: group A (300ml of 22.5% glucose) and group B (300ml of 22.5% fructose).Volunteer was randomized into either group A or B, after an 8-h overnight fasting, took 300ml of solution at 0830 within 5 minutes. After one-week washout period, volunteer was crossed over for either group B or A. each intervention, venous blood was collected at 0h, 0.5h, 1h, 2h, and 3h and blood pressure was tested at 0h, 1h, 2h, and 3h.

Study Timeline

• Study Start: 2015-03
• Primary Completion: 2015-06
• Study Completion: 2015-06
• Status Verified: 2015-10
• Study First Submitted: 2015-10-25
• Study First Submitted QC: 2015-10-28
• Last Update Submitted: 2015-10-28
• Study First Posted: 2015-10-29
• Last Update Posted: 2015-10-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Inclusion criteria were aged 19-39 years, with BMI between 18-24 kg/m 2.

Exclusion Criteria

• Subjects pregnant or having a history of hepatic or renal disease, fructose intolerance, gout, hypoglycemia, or diabetes mellitus were excluded.
• Subjects taking any drugs, botanicals, or nutraceutical known to influence blood pressure also were rejected either.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
serum uric acid	3 hours	Serum uric acid concentration was analyzed on HITACHI 7020 chemistry analyzer using enzyme-based colorimetric test or colorimetric test supplied by DiaSys Diagnostic Systems (Shanghai) Co., Ltd

Secondary Outcome Measures

Name	Time	Method
blood pressure	3 hours	Blood pressure was measured at Zhejiang University Hospital by the research workers who were blind to the groups within 3 hours blood collection.

Trial Locations

Locations (1)

Zhejiang university; 🇨🇳 Hangzhou, Zhejiang, China