Glucose and Fructose Stimulated Brain Activity in Obese Subjects

Not Applicable

Completed

• Conditions: Exploratory Behavior

• Registration Number: NCT02589613
• Lead Sponsor: University Hospital, Basel, Switzerland

Brief Summary

The objective is to investigate neuro-anatomical correlates of the regulation of energy intake by means of functional MRI. Administration of glucose as well as fructose is followed by functional brain MRI, and findings are correlated with serum glucagon-like peptide 1 (GLP-1) levels as an endogenous satiety signal in obese humans.

Detailed Description

Not available

Study Timeline

• Study Start: 2013-10
• Primary Completion: 2014-06
• Study Completion: 2014-06
• Status Verified: 2015-10
• Study First Submitted: 2015-10-20
• Study First Submitted QC: 2015-10-26
• Last Update Submitted: 2015-10-26
• Study First Posted: 2015-10-28
• Last Update Posted: 2015-10-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 12

Inclusion Criteria

• right-handed healthy males, no drugs, non-smoking

Exclusion Criteria

• drug abuse, smoker, left-handed, claustrophobia

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
Functional magnetic resonance imaging (fMRI) in healthy, obese volunteers while they performed a working memory task: changes in cerebral blood flow	changes from baseline to one hour after treatment

Secondary Outcome Measures

Name	Time	Method
Changes in plasma insulin	changes from baseline to one hour after treatment
Changes in plasma GLP-1	changes from baseline to one hour after treatment
Changes in plasma glucose	changes from baseline to one hour after treatment