A Comparison of the Neurocognitive and Metabolic Effects of Fructose, Glucose, High Fructose Corn Syrup and Sucrose at Normal Population Consumed Levels in Adults Ages 20-60 Years Old
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 225
- 试验地点
- 2
- 主要终点
- Change in glucose tolerance
研究概览
简要总结
The purpose of this study is to investigate the acute and chronic effects of consumption fructose containing sugars and glucose in a real word setting when consumed in a manner and amount typical in the American diet.
详细描述
Detailed description (Why and How?) Fructose is known to be metabolized differently than the other common monosaccharides. In addition to the well know lipogenic effects, more recent evidence has shown that the acute changes in hormones and metabolic parameters that control appetite and energy regulation when with fructose consumption may promote caloric overconsumption and, in the long-term, weight gain and deteriorations in insulin sensitivity. However, fructose is rarely consumed in isolation, but instead is consumed in combination with other sugars (with glucose in the case of the two most common sources of fructose: high fructose corn syrup (HFCS) and sucrose, or as part of a mixed macronutrient meal. As such, the practical significance of these short-term findings of isolated monosaccharide consumption is limited.
AIM 1: investigate the response to ten weeks of daily consumption of typical levels of different fructose containing sugars and glucose on measures of glucose and insulin metabolism.
AIM 2: To investigate whether ten weeks of daily consumption changes the fat content of the liver, skeletal muscles or abdomen.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Male or female between the ages of 20-60 years of age.
- •Body Mass Index (BMI) 21.0 - 35.0
排除标准
- •More than a 3 percent change in weight within the 3 months prior to enrollment in the study.
- •History of thyroid disease, but not taking medication or medication dosage changed one or more times over last 6 months. History of thyroid disease and on a stable dose of prescription medication for 6 months or longer is acceptable.
- •Currently taking a prescription medication for weight loss. If subject is willing to discontinue prescription medication(s) immediately and willing to refrain from taking medication(s) for duration of study, he/she may be enrolled after a four-week washout period.
- •Currently taking any over-the-counter weight loss supplement(s). If subject is willing to discontinue supplement(s) immediately and willing to refrain from taking supplement(s) for duration of study, he/she may be enrolled after a two-week washout period.
- •Currently enrolled in commercial weight loss program (e.g. Jenny Craig, Weight Watchers) or self-help group (e.g. TOPS, Overeaters Anonymous). If subject is willing to discontinue program immediately and willing to refrain from program for duration of study, he/she may be included after a two-week washout period.
- •Diagnosed with prediabetes or frank diabetes (Type I or Type II).
- •History of major surgery within three months of enrollment.
- •History of heart problems (e.g. angina, bypass surgery, MI, etc.) within three months prior to enrollment.
- •Presence of implanted cardiac defibrillator or pacemaker.
- •Uncontrolled hypertension/high blood pressure.
- •History of a surgical procedure for weight loss at any time (e.g. gastroplasty, gastric by-pass, gastrectomy or partial gastrectomy).
- •Gastrointestinal disorders including chronic malabsorptive conditions, peptic ulcer disease, Crohn's disease, chronic diarrhea or active gallbladder disease.
- •History of inflammatory bowel disease
- •History of fatty liver
- •History or presence of cancer. Persons with successfully resected basal cell carcinoma of the skin may be enrolled if treatment completed more than 6 months prior to enrollment.
- •History of clinically diagnosed eating disorders including anorexia nervosa, bulimia nervosa or binge eating disorder.
- •Women who are pregnant, lactating or trying to become pregnant.
- •Currently taking any prescription medication for less than 3 months.
- •Currently consuming >14 alcoholic drinks (1 drink = 12 fl oz beer, 4 fl oz wine or 1.5 fl oz liquor) per week and/or unwilling to limit intake to less than 3 drinks per week during study participation.
- •Known allergy to HFCS, sucrose, fructose or glucose.
- •History of alcohol dependency
- •Participation in another clinical trial within 30 days prior to enrollment.
- •Lactose intolerance
- •Currently smoking cigarettes
- •Any clinically significant food allergy
结局指标
主要结局
Change in glucose tolerance
时间窗: 10 weeks (Baseline and week 10)
Change in glucose Area Under the Curve (AUC) in response to a standard 2 hour Oral Glucose Tolerance Test
Change in Insulin Sensitivity
时间窗: 10 weeks (Baseline and week 10)
Change in 1) insulin AUC in response to a standard 2 hour Oral Glucose and Matsuda Insulin Sensitivity Index
次要结局
- Change in fat content of the liver(10 weeks (baseline and Week 10))
- Change in fat content of the abdomen(10 weeks (baseline and Week 10))
- Change in fat content of the skeletal muscles(10 weeks (baseline and Week 10))
- Change in hypothalamic activity(10 weeks (baseline and Week 10))