The Role of Endogenous GLP-1 (Glycolipoprotein) in Regulating Glucose Stimulated Brain Activity

Not Applicable

Completed

• Conditions: Exploratory Behavior

• Registration Number: NCT01918566
• Lead Sponsor: University Hospital, Basel, Switzerland

Brief Summary

Our objective is to investigate neuro-anatomical correlates of the regulation of energy intake by means of functional MRI. Administration of glucose with and without lactisole and exendin as well as fructose is followed by functional brain MRI, and findings are correlated with serum GLP-1 levels as an endogenous satiety signal in humans.

Detailed Description

Not available

Study Timeline

• Study Start: 2012-03
• Primary Completion: 2013-03
• Study Completion: 2013-03
• Study First Submitted: 2013-05-08
• Status Verified: 2013-08
• Study First Submitted QC: 2013-08-05
• Last Update Submitted: 2013-08-05
• Study First Posted: 2013-08-07
• Last Update Posted: 2013-08-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 12

Inclusion Criteria

• right-handed healthy males, no drugs, non-smoking

Exclusion Criteria

• drug abuse, smoker, left-handed, claustrophobia

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
Functional magnetic resonance imaging (fMRI) in healthy volunteers while they performed a working memory task: changes in cerebral blood flow and blood hormones from baseline to treatment	changes from baseline to one hour after treatment	Whole brain analysis with a cluster-level threshold was followed by an a priori defined region of interest analysis of the dorsolateral prefrontal cortex including a cluster-level threshold and family-wise error adjustment for multiple comparisons.

Trial Locations

Locations (1)

University Hospital; 🇨🇭 Basel, Switzerland