Effect of transient high blood glucose on brachial artery functio

Completed

• Conditions: cardiovascular disease; endothelial dysfunction; 10012653; 10003216

• Registration Number: NL-OMON34359
• Lead Sponsor: Medisch Universitair Ziekenhuis Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 30

Inclusion Criteria

male, aged 18+, fasting glucose below 6.1 mmol/l (point-of-care blood test, see E.6, item 2.)

Exclusion Criteria

Female
Non-compliance with one of the following fasting requirements 12 hours prior to measurement:
* Medication
* Smoking
* Caffeine
* Vitamin supplements
* Exercise
* Food and drinks (only water permitted till 3 hours prior to measurements)
Fasting blood glucose level higher than 6.1 mmol/l (point-of-care meter; capillary blood sample).

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>FMD, local brachial artery pressure and cyclic change in diameter (distension)<br /><br>as a function of blood glucose en insulin concentrations.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Correlations of selected biomarkers of endothelial function with mentioned<br /><br>primary study parameters. Also changes therein as a function of blood glucose<br /><br>en insulin concentrations.</p><br>