TAPUR: Testing the Use of Food and Drug Administration (FDA) Approved Drugs That Target a Specific Abnormality in a Tumor Gene in People With Advanced Stage Cancer

Phase 2

Recruiting

• Conditions: Lymphoma, Non-Hodgkin; Multiple Myeloma; Advanced Solid Tumors
• Interventions: Drug: Sunitinib; Drug: Vemurafenib and Cobimetinib; Drug: Palbociclib; Drug: Nivolumab and Ipilimumab; Drug: Abemaciclib; Drug: Atezolizumab and PHESGO; Drug: Atezolizumab and Talazoparib; Drug: Futibatinib; Drug: Trastuzumab and Pertuzumab; Drug: Tucatinib plus Trastuzumab Subcutaneous (SC); Drug: Talazoparib; Drug: Temsirolimus; Drug: Regorafenib; Drug: Olaparib; Drug: Pembrolizumab; Drug: Entrectinib; Drug: Larotrectinib

• Registration Number: NCT02693535
• Lead Sponsor: American Society of Clinical Oncology

Brief Summary

The purpose of the study is to learn from the real world practice of prescribing targeted therapies to patients with advanced cancer whose tumor harbors a genomic variant known to be a drug target or to predict sensitivity to a drug.

NOTE: Due to character limits, the arms section does NOT include all TAPUR Study relevant biomarkers. For additional information, contact TAPUR@asco.org, or if a patient, your nearest participating TAPUR site (see participating centers).

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Results in publication or poster presentation format are posted as they become available for individual cohorts at www.tapur.org/news. The results may be accessed at any time. All results will be made available on clinicaltrials.gov at the end of the study. Indexing of available results on PubMed is in progress.

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Detailed Description

The Targeted Agent and Profiling Utilization Registry (TAPUR) Study is a non-randomized clinical trial that aims to describe the safety and efficacy of commercially available, targeted anticancer drugs prescribed for treatment of patients with advanced cancer that has a potentially actionable genomic variant. TAPUR will study Food and Drug Administration (FDA)-approved targeted therapies that are contributed by collaborating pharmaceutical companies, catalogue the choice of molecular profiling test by clinical oncologists and develop hypotheses for additional clinical trials.

Study Timeline

• Study First Submitted: 2016-02-11
• Study First Submitted QC: 2016-02-23
• Study First Posted: 2016-02-26
• Study Start: 2016-03-14
• Status Verified: 2024-11
• Last Update Submitted: 2024-12-23
• Last Update Posted: 2024-12-27
• Primary Completion: 2026-06-30
• Study Completion: 2027-06-30

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 3791

Inclusion Criteria

• 12 years of age or older (*Restrictions apply. Not all therapies are available for patients <18)

• Histologically-proven locally advanced or metastatic solid tumor, multiple myeloma or B cell non-Hodgkin lymphoma who is no longer benefiting from standard anti-cancer treatment or for whom, in the opinion of the treating physician, no such treatment is available or indicated

• Performance status 0-2 (Per Eastern Cooperative Oncology Group (ECOG) criteria)

• Patients must have acceptable organ function as defined below. However, as noted above, drug-specific inclusion/exclusion criteria specified in the protocol appendix for each agent will take precedence for this and all inclusion criteria:

  1. Absolute neutrophil count ≥ 1.5 x 106/µl
  2. Hemoglobin > 9.0 g/dl
  3. Platelets > 75,000/µl
  4. Total bilirubin < 2.0 mg/ dl, except in patients with Gilbert's Syndrome
  5. Aspartate aminotransferase (AST) serum glutamic-oxaloacetic transaminase (SGOT) and alanine aminotransferase (ALT) serum glutamic-pyruvic transaminase (SGPT) < 2.5 x institutional upper limit of normal (ULN) (or < 5 x ULN in patients with known hepatic metastases)
  6. Serum creatinine ≤ 1.5 × ULN or calculated or measured creatinine clearance ≥ 50 mL/min/1.73 m2

• Patients must have disease that can be objectively measured by physical or radiographic exam (per RECIST v1.1 for solid tumor, Lugano criteria for non-Hodgkin lymphoma or International Myeloma Working Group criteria for multiple myeloma), defined as at least one lesion that can be accurately measured in at least one dimension (longest diameter to be recorded for non-nodal lesions and short axis for nodal lesions) as ≥20 mm with conventional techniques or as ≥10 mm with spiral CT scan, MRI, or a subcutaneous or superficial lesion that can be measured with calipers by clinical exam. For lymph nodes, the short axis must be ≥15 mm. Patient's whose disease cannot be objectively measured by physical or radiographic examination (e.g., elevated serum tumor marker only, bone-only disease without an identifiable soft tissue component, or patients with only assessable non-measurable disease) are NOT eligible.

• Results must be available from a genomic test or immunohistochemistry (IHC) test for protein expression performed in a Clinical Laboratory Improvement Amendments (CLIA)-certified and College of American Pathologists (CAP)-accredited or New York State accredited (for labs offering services to residents of NY) laboratory. Labs that have registered the test with the NIH Genetic Testing Registry or that provide a report that has been designated as optimized for TAPUR participation are preferred, but not required. The genomic or IHC test used to qualify a patient for participation in TAPUR may have been performed on any specimen of the patient's tumor obtained at any point during the patient's care at the discretion of the patient's treating physician. Genomic assays performed on cell-free DNA in plasma ("liquid biopsies") will also be acceptable if the genomic analysis is performed in a laboratory that meets the criteria described above.

• Ability to understand and the willingness to sign a written informed consent/assent document.

• Have a tumor genomic profile for which single agent treatment with one of the FDA approved targeted anti-cancer drugs included in this study has potential clinical benefit based on the criteria described in protocol.

• For orally administered drugs, the patient must be able to swallow and tolerate oral medication and must have no known malabsorption syndrome.

• Because of the risks of drug treatment to the developing fetus, women of child-bearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) for the duration of study participation, and for four months following completion of study therapy. Should a woman become pregnant or suspect she is pregnant while participating in this study or if she is the partner of a male participant in this study and becomes pregnant while he is participating in this study, she should inform her or her partner's treating physician immediately as well as her obstetrician. Female study patients who become pregnant must immediately discontinue treatment with any study therapy. Male patients should avoid impregnating a female partner. Male study patients, even if surgically sterilized, (i.e. post-vasectomy) must agree to one of the following: practice effective barrier contraception during the entire study treatment period and for a specified amount of time the last dose of study drug, or completely abstain from sexual intercourse.

Note: TAPUR does not explicitly exclude any type of solid tumor, but the patient must have measurable and evaluable disease per RECIST v1.1.

Read More

Exclusion Criteria

• Patients whose disease is not measurable or cannot be assessed by radiographic imaging or physical examination (e.g., elevated serum tumor marker only) are not eligible
• Patients with primary brain tumors or leptomeningeal metastases are excluded.
• Patients with previously treated brain metastases are eligible, provided that the patient has not experienced a seizure or had a clinically significant change in neurological status within the 3 months prior to registration. All patients with previously treated brain metastases must be clinically stable for at least 1 month after completion of treatment and off steroid treatment for one month prior to study enrollment.
• Patients with known progressive brain metastases are eligible but additional eligibility criteria apply.

Note: there are additional exclusion criteria that may apply

Read More

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Group 5 (CSF1R,PDGFR,VEGFR)	Sunitinib	Participants receive sunitinib - dosage, frequency and duration per label; acceptable genomic matches include CSF1R, PDGFR, VEGFR1/2/3, KIT, FLT-3, RET, FGFR1/2/3, VHL amplifications or mutations
Group 9 (BRAF V600E/D/K/R)	Vemurafenib and Cobimetinib	Participants receive vemurafenib and cobimetinib - dosage, frequency and duration per label; acceptable genomic matches include BRAF V600E/D/K/R mutations
Group 4 (CDKN2A, CDK4, CDK6)	Palbociclib	Participants receive palbociclib - dosage, frequency and duration per label; acceptable genomic matches include CDKN2A loss or mutation, CDK4, CDK6 amplifications, CDKN2B loss or mutation
Group 16 (MSI-H, high mutational load and others)	Nivolumab and Ipilimumab	Participants receive nivolumab and ipilimumab - dosage, frequency and duration per label; acceptable genomic matches include MSI high status, high tumor mutational burden, MLH1, MSH2/6, PMS2, EPCAM mutations, specific POLE or POLD1 mutations, BRCA1/2, ATM, MSH3, PMS1, MLH3, EXO1, RFC1/2/3/4/5, PCNA, RPA1/2/3/4, and SSBP1 loss of function mutations
Group 17 (CDKN2A, CDK4, CDK6)	Abemaciclib	Participants receive abemaciclib - dosage, frequency and duration per label; acceptable genomic matches include CDKN2A loss or mutation, CDK4, CDK6 amplifications, CDKN2B loss or mutation
Group 20 (ERBB2)	Atezolizumab and PHESGO	Participants receive atezolizumab plus PHESGO - dosage, frequency and duration per label; acceptable genomic matches include ERBB2 amplification or overexpression
Group 21 (BRCA1/2, PALB2, ATM, and others)	Atezolizumab and Talazoparib	Participants receive atezolizumab plus talazoparib - dosage, frequency and duration per label; acceptable genomic matches include germline or somatic mutations in BRCA1/2, PALB2, ATM, ATR, CHEK2, FANCA, RAD51C, NBN, MLH1, MRE11A, CDK12; positive genomic instability score reported on the Myriad MyChoice CDx test; or Genomic Loss of Heterozygosity (LOH) Score above threshold as reported on a FoundationOne CDx test or another qualifying test for TAPUR with MTB approval
Group 25	Futibatinib	Participants receive futibatinib- dosage, frequency and duration per label; acceptable genomic matches include FGFR 1,2,3,4 fusion (or other rearrangement) or mutation
Group 8 (ERBB2)	Trastuzumab and Pertuzumab	Participants receive trastuzumab and pertuzumab - dosage, frequency and duration per label; acceptable genomic matches include ERBB2 amplification or overexpression, and specific ERBB2 mutations
Group 24 (ERBB2)	Tucatinib plus Trastuzumab Subcutaneous (SC)	Participants receive tucatinib plus trastuzumab SC - dosage, frequency and duration per label; acceptable genomic matches include ERBB2 amplification or overexpression, and specific ERBB2 mutations
Group 19 (BRCA1/2, PALB2)	Talazoparib	Participants receive talazoparib - dosage, frequency and duration per label; acceptable genomic matches include germline or somatic BRCA1/2 and PALB2 mutations
Group 6 (mTOR, TSC)	Temsirolimus	Participants receive temsirolimus - dosage, frequency and duration per label; acceptable genomic matches include mTOR, TSC1/2, AKT1 mutations
Group 13 (RET,VEGFR1/2/3,KIT,PDGFRβ,RAF-1,BRAF)	Regorafenib	Participants receive regorafenib - dosage, frequency and duration per label; acceptable genomic matches include RET, VEGFR1/2/3, KIT, PDGFRβ, RAF-1, BRAF mutations or amplifications
Group 14 (BRCA1/2; ATM)	Olaparib	Participants receive olaparib - dosage, frequency and duration per label; acceptable genomic matches include germline or somatic BRCA1/2 inactivating mutations; ATM mutations or deletions
Group 15 (POLE, POLD1)	Pembrolizumab	Participants receive pembrolizumab - dosage, frequency and duration per label; acceptable genomic matches include specific POLE and POLD1 mutations
Group 22 (ROS1 fusion)	Entrectinib	Participants receive entrectinib - dosage, frequency and duration per label; acceptable genomic matches include any ROS1 fusion
Group 23 (NTRK amplification)	Larotrectinib	Participants receive larotrectinib - dosage, frequency and duration per label; acceptable genomic matches include NTRK1/2/3 amplification

Primary Outcome Measures

Name	Time	Method
Objective Response Rate defined as % of participants in a cohort with complete or partial response or with stable disease according to standard response criteria	Assessed at 16 weeks of treatment	Each cohort includes participants with the same tumor type, genomic variant and study drug. For solid tumors, the Response Evaluation Criteria for Solid Tumors (RECIST) criteria will be used, for non-Hodgkin Lymphoma, the Lugano Criteria will be used, and for multiple myeloma, the International Uniform Response Criteria for Multiple Myeloma will be used.

Secondary Outcome Measures

Name	Time	Method
Overall survival (OS)	Duration of survival from registration on study until death from any cause, assessed throughout end of study, up to 3 years	OS will be estimated using the Kaplan-Meier method

Trial Locations

Locations (128)

University of Alabama at Birmingham Comprehensive Cancer Center; 🇺🇸 Birmingham, Alabama, United States

Cancer Treatment Centers of America-Phoenix; 🇺🇸 Phoenix, Arizona, United States

Sutter Auburn; 🇺🇸 Auburn, California, United States

Sutter Alta Bates; 🇺🇸 Berkeley, California, United States

The Angeles Clinic and Research Institute, A Cedars-Sinai Affiliate; 🇺🇸 Los Angeles, California, United States

Kaiser Permanente - Oakland Medical Center; 🇺🇸 Oakland, California, United States

Sutter Palo Alto Medical Foundation: Palo Alto; 🇺🇸 Palo Alto, California, United States

Kaiser Permanente - Roseville Medical Center; 🇺🇸 Roseville, California, United States

Sutter Roseville; 🇺🇸 Roseville, California, United States

Kaiser Permanente - Sacramento Medical Center; 🇺🇸 Sacramento, California, United States

Sutter Sacramento; 🇺🇸 Sacramento, California, United States

Kaiser Permanente - South San Francisco Medical Center; 🇺🇸 San Francisco, California, United States

California Pacific Medical Center Research Institute; 🇺🇸 San Francisco, California, United States

Kaiser Permanente - San Francisco Medical Center; 🇺🇸 San Francisco, California, United States

Sutter Cancer Research Consortium; 🇺🇸 San Francisco, California, United States

Kaiser Permanente - San Jose Medical Center; 🇺🇸 San Jose, California, United States

Kaiser Permanente - San Leandro Medical Center; 🇺🇸 San Leandro, California, United States

Kaiser Permanente - Santa Clara Medical Center; 🇺🇸 Santa Clara, California, United States

Sutter Palo Alto Medical Foundation: Santa Cruz; 🇺🇸 Santa Cruz, California, United States

Sutter Palo Alto Medical Foundation: Fremont; 🇺🇸 Santa Cruz, California, United States

Sutter Palo Alto Medical Foundation: Sunnyvale; 🇺🇸 Sunnyvale, California, United States

Kaiser Permanente - Vallejo Medical Center; 🇺🇸 Vallejo, California, United States

Kaiser Permanente - Walnut Creek Medical Center; 🇺🇸 Walnut Creek, California, United States

Saint Vincent's Medical Center (SVMC); 🇺🇸 Bridgeport, Connecticut, United States

Hartford Hospital; 🇺🇸 Hartford, Connecticut, United States

Midstate Medical Center (MSMC); 🇺🇸 Meriden, Connecticut, United States

The Hospital of Central Connecticut (HOCC) Cancer Center; 🇺🇸 New Britain, Connecticut, United States

William W. Backus Hospital; 🇺🇸 Norwich, Connecticut, United States

Charlotte Hungerford; 🇺🇸 Torrington, Connecticut, United States

Windham Hospital (WH); 🇺🇸 Willimantic, Connecticut, United States

Florida Cancer Specialists North / Sarah Cannon Research Institute; 🇺🇸 Winter Park, Florida, United States

Florida Cancer Specialists South / Sarah Cannon Research Institute; 🇺🇸 Venice, Florida, United States

Florida Cancer Specialists East / Sarah Cannon Research Institute; 🇺🇸 West Palm Beach, Florida, United States

Holy Cross Hospital; 🇺🇸 Fort Lauderdale, Florida, United States

University of Florida Health; 🇺🇸 Gainesville, Florida, United States

University of Miami Sylvester Comprehensive Cancer Center; 🇺🇸 Miami, Florida, United States

Cancer Treatment Centers of America - Atlanta; 🇺🇸 Atlanta, Georgia, United States

Emory University Winship Cancer Institute; 🇺🇸 Atlanta, Georgia, United States

Gynecologic Oncology and Surgical Specialists at the Lewis Cancer & Research Pavilion; 🇺🇸 Savannah, Georgia, United States

Lewis Cancer & Research Pavilion at the Melanoma, Skin Cancer & Sarcoma Institute; 🇺🇸 Savannah, Georgia, United States

Lewis Cancer & Research Pavilion; 🇺🇸 Savannah, Georgia, United States

Summit Cancer Care; 🇺🇸 Savannah, Georgia, United States

The Queen's Medical Center (The University of Texas MD Anderson Cancer Center); 🇺🇸 Honolulu, Hawaii, United States

Cancer Treatment Centers of America-Chicago; 🇺🇸 Chicago, Illinois, United States

Community Health Network (The University of Texas MD Anderson Cancer Center); 🇺🇸 Indianapolis, Indiana, United States

Harold Alfond Center for Cancer Care; 🇺🇸 Augusta, Maine, United States

Jackson Laboratory - Maine Cancer Genomics Initiative; 🇺🇸 Augusta, Maine, United States

Waldo County General Hospital; 🇺🇸 Belfast, Maine, United States

SMHC Cancer Care and Blood Disorders -Biddeford; 🇺🇸 Biddeford, Maine, United States

Northern Light Cancer Care; 🇺🇸 Brewer, Maine, United States

Raish Peavey Haskell Children's Cancer and Treatment Center; 🇺🇸 Brewer, Maine, United States

MaineHealth Cancer Care -Brunswick; 🇺🇸 Brunswick, Maine, United States

New England Cancer Specialist; 🇺🇸 Portsmouth, New Hampshire, United States

York Hopsital Oncology & Infusion Care in Kittery; 🇺🇸 Kittery, Maine, United States

Stephens Memorial Hospital; 🇺🇸 Norway, Maine, United States

Penobscot Bay Medical Center; 🇺🇸 Rockport, Maine, United States

SMHC Cancer Care and Blood Disorders -Sandford; 🇺🇸 Sanford, Maine, United States

Maine Children's Cancer Program; 🇺🇸 Scarborough, Maine, United States

Maine Medical Partner's Women's Health; 🇺🇸 Scarborough, Maine, United States

MaineHealth Cancer Care -South Portland; 🇺🇸 South Portland, Maine, United States

York Hospital Oncology & Infusion Care in Wells; 🇺🇸 Wells, Maine, United States

York Hospital Oncology & Infusion Care in York; 🇺🇸 York, Maine, United States

Trinity Health Ann Arbor Hospital; 🇺🇸 Ann Arbor, Michigan, United States

University of Michigan; 🇺🇸 Ann Arbor, Michigan, United States

Ascension St. John Hospital; 🇺🇸 Detroit, Michigan, United States

Genesys Hurley Cancer Institute; 🇺🇸 Grand Blanc, Michigan, United States

Cancer Research Consortium of West Michigan; 🇺🇸 Grand Rapids, Michigan, United States

Sparrow Hospital; 🇺🇸 Lansing, Michigan, United States

Trinity Health Livonia Hospital; 🇺🇸 Livonia, Michigan, United States

Trinity Health Oakland Hospital; 🇺🇸 Pontiac, Michigan, United States

Ascension St. Mary's Hospital; 🇺🇸 Saginaw, Michigan, United States

Michigan Cancer Research Consortium; 🇺🇸 Traverse City, Michigan, United States

St. John Macomb Oakland Hospital; 🇺🇸 Warren, Michigan, United States

University of Nebraska Medical Center; 🇺🇸 Omaha, Nebraska, United States

NH Oncology - Hematology, PA; 🇺🇸 Concord, New Hampshire, United States

Solinsky Center for Cancer Care; 🇺🇸 Manchester, New Hampshire, United States

Lovelace Medical Center - Saint Joseph Square; 🇺🇸 Albuquerque, New Mexico, United States

Presbyterian Kaseman Hospital; 🇺🇸 Albuquerque, New Mexico, United States

The University of New Mexico Comprehensive Cancer Center; 🇺🇸 Albuquerque, New Mexico, United States

Memorial Medical Center; 🇺🇸 Las Cruces, New Mexico, United States

Presbyterian Rust Medical Center; 🇺🇸 Rio Rancho, New Mexico, United States

Northwell Health Monter Cancer Center; 🇺🇸 Lake Success, New York, United States

Cohen Children's Medical Center; 🇺🇸 New Hyde Park, New York, United States

Herbert Irving Comprehensive Cancer Center; 🇺🇸 New York, New York, United States

Manhattan Eye, Ear, and Throat Hospital; 🇺🇸 New York, New York, United States

Staten Island University Hospital; 🇺🇸 New York, New York, United States

Phelps Hospital; 🇺🇸 Sleepy Hollow, New York, United States

Lineberger Comprehensive Cancer Center; 🇺🇸 Chapel Hill, North Carolina, United States

Atrium Health's Levine Cancer Institute; 🇺🇸 Charlotte, North Carolina, United States

Sanford Health- Bismarck; 🇺🇸 Bismarck, North Dakota, United States

Sanford Health- Fargo; 🇺🇸 Fargo, North Dakota, United States

University of Cincinnati Medical Center; 🇺🇸 Cincinnati, Ohio, United States

Kettering Health; 🇺🇸 Kettering, Ohio, United States

West Chester Hospital; 🇺🇸 West Chester, Ohio, United States

Providence Health & Services; 🇺🇸 Portland, Oregon, United States

Lehigh Valley Health Network; 🇺🇸 Allentown, Pennsylvania, United States

Lehigh Valley Hospital- Muhlenberg; 🇺🇸 Bethlehem, Pennsylvania, United States

Pocono Medical Center; 🇺🇸 East Stroudsburg, Pennsylvania, United States

Lehigh Valley Hospital-Hazleton; 🇺🇸 Hazleton, Pennsylvania, United States

Fox Chase Cancer Center; 🇺🇸 Philadelphia, Pennsylvania, United States

SC Cancer Specialists at St. Joseph's/Candler Bluffton; 🇺🇸 Bluffton, South Carolina, United States

St. Joseph's/Candler Smith; 🇺🇸 Bluffton, South Carolina, United States

Summit Cancer Care at St. Josph's/Candler Bluffton; 🇺🇸 Bluffton, South Carolina, United States

South Carolina Cancer Specialists; 🇺🇸 Hilton Head Island, South Carolina, United States

Sanford Cancer Center Oncology Clinic and Pharmacy; 🇺🇸 Sioux Falls, South Dakota, United States

Tennessee Oncology - Nashville / Sarah Cannon Research Institute; 🇺🇸 Nashville, Tennessee, United States

The University of Texas MD Anderson Cancer Center; 🇺🇸 Houston, Texas, United States

Cedar City Hospital, SW Cancer Clinic, Sandra Maxwell Cancer Center; 🇺🇸 Cedar City, Utah, United States

Dixie Regional Medical Center-River Road Campus; 🇺🇸 Saint George, Utah, United States

Intermountain Healthcare; 🇺🇸 Salt Lake City, Utah, United States

Inova Schar Cancer Institute; 🇺🇸 Fairfax, Virginia, United States

Swedish Cancer Institute; 🇺🇸 Seattle, Washington, United States

Aurora Cancer Care - Burlington; 🇺🇸 Burlington, Wisconsin, United States

Aurora Health Care - Germantown Health Center; 🇺🇸 Germantown, Wisconsin, United States

Aurora Cancer Care - Grafton; 🇺🇸 Grafton, Wisconsin, United States

Aurora BayCare Medical Center; 🇺🇸 Green Bay, Wisconsin, United States

Aurora Cancer Care - Kenosha South; 🇺🇸 Kenosha, Wisconsin, United States

Aurora Bay Area Medical Center; 🇺🇸 Marinette, Wisconsin, United States

Aurora Cancer Care Milwaukee; 🇺🇸 Milwaukee, Wisconsin, United States

Aurora St. Luke's Medical Center; 🇺🇸 Milwaukee, Wisconsin, United States

Aurora Sinai Medical Center; 🇺🇸 Milwaukee, Wisconsin, United States

Aurora West Allis Medical Center; 🇺🇸 Milwaukee, Wisconsin, United States

Vince Lombardi Cancer Clinic - Oshkosh; 🇺🇸 Oshkosh, Wisconsin, United States

Aurora Cancer Care - Racine; 🇺🇸 Racine, Wisconsin, United States

Vince Lombardi Cancer Center; 🇺🇸 Sheboygan, Wisconsin, United States

Aurora Medical Center in Summit; 🇺🇸 Summit, Wisconsin, United States

Vince Lombardi Cancer Clinic - Two Rivers; 🇺🇸 Two Rivers, Wisconsin, United States

Aurora Cancer Care - Milwaukee West; 🇺🇸 Wauwatosa, Wisconsin, United States