Is stroke neurodegenerative? A longitudinal study of changes in brain volume and cognition following stroke (CANVAS: Cognition And Neocortical Volume After Stroke)

Not Applicable

Active, not recruiting

• Conditions: Ischaemic stroke; Alzheimer's disease; Stroke - Ischaemic; Neurological - Alzheimer's disease

• Registration Number: ACTRN12616000970448
• Lead Sponsor: Austin Health

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2016-07-25
• Last Update Posted: 3 March 2020

Recruitment & Eligibility

• Status: Active, not recruiting
• Sex: All
• Target Recruitment: 175

Inclusion Criteria

Inclusion criteria for the stroke group include:

1. Clinical ischaemic stroke;
2. Aged greater than 18 years;
3. Able to have cognitive testing and MRI scan; and
4. Able to give informed consent.

Inclusion criteria for healthy controls are the same, excluding, of course, the stroke diagnosis.

Exclusion Criteria

Exclusion criteria for stroke patients and control participants are the same. These include:

1. Significant medical comorbidities precluding participation in cognitive testing, or making survival for 3 years unlikely;

2. Normal exclusion criteria for MRI; e.g., implanted metal, severe claustrophobia;

3. Pre-existing dementia;

4. Pregnancy, as a precaution to prevent exposing them to multiple MRI scans in a 12-month period;

5. People in existing dependent or unequal relationships with any member of research team, to protect against coercion.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Our primary imaging outcome is brain volume change at 3 months versus 3 years, as measured by 3T MRI. We expect that stroke patients will exhibit greater and more rapid loss of whole brain and hippocampal volume, over time, than controls. <br><br>[3 years post-stroke.];Our primary cognitive outcome is a dementia diagnosis, in a proportion of stroke patients, at 3 years. Cognitive test scores will be reviewed, and participants who are thought to have a dementia will be referred on to appropriate members of Austin Health, who are not part of the research team, for formal neuropsychological assessment. <br><br>We expect that loss of brain volume will be associated with subsequent cognitive decline. [3 years post-stroke.]

Secondary Outcome Measures

Name	Time	Method
Hippocampal volume at 3 months, as measured by structural magnetic resonance imaging, will be predictive of a dementia diagnosis at 3 years post-stroke. A dementia diagnosis will be made by members of Austin Health, who are not part of the research team.[3 years post-stroke.]