A randomised double blind placebo controlled pilot trial of oxytocin efficacy in treating detoxified opioid dependent individuals - Pilot RCT of oxytocin for the treatment of opioid dependence

niversity of Surrey0 个研究点目标入组 3 人开始时间: 2014年11月6日最近更新: 2019年6月30日

适应症

试验速览

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•1) Primary diagnosis of opioid dependence according to DSMIV criteria
•2) Males and non-lactating, non-pregnant females, aged 18-65 years.
•3) Patients must be willing and able to give informed consent
•4) Patients must have understanding of English
•5) Patients are required to have completed opiate detoxification programme at Windmill House and remain opiate free before the start of the study. These patients will continue with a specific opiate free inpatient programme at Windmill House. The programme runs 6 days a week, with daily groups comprising a mixture of cognitive behaviour therapy (CBT), psychodynamic and recovery related groups.
•Are the trial subjects under 18? no
•Number of subjects for this age range: 0
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range 30
•F.1.3 Elderly (>=65 years) no
•F.1.3.1 Number of subjects for this age range 0

•1) Severe psychosis, Bipolar Affective Disorder I, severe depression with suicidal ideation and intention, brain trauma or other severe neurological disorders (e.g. pan-hypopituitarism).
•2) Taking anxiolytics antipsychotics, sedatives, opioids for pain management during post opiate detoxification.
•3) Pregnant females and lactating mothers
•4) History of severe kidney disease
•5) History of cardiovascular disease (heart disease, heart attacks, abnormally high blood pressure)
•6) Habitual drinking of large volumes of water
•7) Nasal bleeding
•8) Any other condition that in the judgement of the investigator would preclude participation

发起方

niversity of Surrey