Analysis of FAZ in Diabetic Retinopathy Using OCT Angiography

Not Applicable

• Conditions: Diabetic Retinopathy
• Interventions: Device: OCT angiography

• Registration Number: NCT05140304
• Lead Sponsor: Kareem Mohammad Ali

Brief Summary

Study and assessment of characteristic changes in foveal avascular zone during different stages of diabetic retinopathy using OCTA.

Detailed Description

OCTA is superior to other retinal imaging techniques like fluorescein angiography(FA) as it does not require dye injection, Intravenous dye injection is time consuming and can have adverse side effects. Furthermore, the edges of the capillaries can become blurred due to dye leakage and imaging of the retina can only be 2D when using FA.

OCTA provides both structural and functional (i.e. blood flow) information in tandem. The "corresponding" OCT b-scans can be co-registered with the simultaneous OCT angiograms so the operator is able to scroll through the OCT angiogram like a cube scan. As a result, the precise location of pathology can be viewed on the corresponding OCT b-scans. This makes OCTA a better tool when detecting the exact location of a retinal pathology.

In diabetic retinopathy OCTA can show choriocapillaris abnormalities and/or retinal microvascular abnormalities such as microaneurysms, vascular remodeling adjacent to the foveal avascular zone (FAZ), enlarged FAZ, and capillary tortuosity and dilation through different stages. OCTA can show smaller vascular changes not detectable by FA.

Study Timeline

• Status Verified: 2021-11
• Study First Submitted: 2021-11-17
• Study First Submitted QC: 2021-11-17
• Last Update Submitted: 2021-11-17
• Study Start: 2021-11-30
• Study First Posted: 2021-12-01
• Last Update Posted: 2021-12-01
• Primary Completion: 2022-10
• Study Completion: 2022-11

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• Diabetic patients suffering from different stages of diabetic retinopathy.

Exclusion Criteria

• Other ocular problems affecting vision including glaucoma, cataract, amblyopia, hypertensive retinopathy, vein occlusion and uveitis.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
A	OCT angiography	-

Primary Outcome Measures

Name	Time	Method
Mean area of FAZ in various stages of diabetic retinopathy and difference between these groups in superficial and deep capillary plexuses	baseline	analysis of foveal avascular zone in different stages of diabetic retinopathy using OCT angiography