OCTA Analysis In Children After Lensectomy
- Conditions
- Deprivation Amblyopia
- Interventions
- Device: Optical Coherence Tomography Angiography
- Registration Number
- NCT04217772
- Lead Sponsor
- Wenzhou Medical University
- Brief Summary
The aim of this study is to quantify and compare the foveal avascular zone (FAZ), the parafoveal and foveal vessel density of superficial (SCP) and deep capillary plexus (DCP) and retinal thickness in deprivation amblyopic eyes, fellow non-amblyopic eyes, and age-matched normal eyes, using optical coherence tomography angiography (OCTA). The FAZ, parafoveal and foveal SCP and DCP, and retinal thickness were measured in normal controls and at least 3 months postoperatively in children with unilateral cataract and compared between groups after adjusting for axial length and spherical equivalents.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 100
- children after cataract surgery and healthy volunteers
- presence of corneal opacity preventing detailed imaging
- nystagmus
- retinal disease,
- persistent fetal vasculature
- intraocular inflammation,
- glaucoma
- vitreoretinal surgery
- premature birth
- neurologic disease
- systemic disease that could alter microvasculature (including diabetes, hypertension, cardiovascular disease and renal disease)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Eyes post-lensectomy Optical Coherence Tomography Angiography Eyes of children after cataract surgery
- Primary Outcome Measures
Name Time Method Area of foveal avascular zone up to 36 months Area of foveal avascular zone in square microns
Foveal retinal thickness up to 36 months Foveal retinal thickness in microns
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (2)
The affiliated Eye Hospital of Wenzhou Medical College
🇨🇳Wenzhou, Zhejiang, China
Eye Hospital of WMU
🇨🇳Hangzhou, Zhejiang, China