Investigation into the protective effects of apple juice on the intestinal barrier in athletes
Not Applicable
Recruiting
- Conditions
- no deseases are investigatedhealthy volunteers
- Registration Number
- DRKS00027860
- Lead Sponsor
- DSHS Köln, Kreislaufforschung und Sportmedizin, Abt.2
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 20
Inclusion Criteria
healthy endurance athletes with an age of 18-60 years
Exclusion Criteria
Hormone substitution; incl. thyroid Hormone therapy
Smokers
One-sided diet (e.g. vegan)
People in need of treatment
Cardiac arrhythmia Heart failure (EF<55)
Performance-limiting pAVK (Fontaine stage = II)
Performance- or training-limiting degenerative joint diseases or muscular diseases
Performance-limiting kidney disease
Performance-limiting neurological disease
oncological diseases in the history (< 5 years)
Psychiatric and/or addictive disorders
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 9ml venous blood sampling at the time points:<br>T0 (start of examination day), T1 (immediately after physical exercise), T2 (+40 min after beverage consumption), T3 (+80 min after beverage consumption), T4 (+120 min after beverage consumption), T5 (+180 min after beverage consumption), T6 (24h after beverage consumption).<br><br>The following parameters should be examined:<br>Intestinal fatty acid-binding proteins (I-FABP), zonulin, lipopolysaccharide binding protein (LBP), bacterial endotoxin, determination of toll-like receptors in isolated peripheral mononuclear cells (PBMC), interleukin 6 and 10 (IL 6, IL 10), macrophage migration inhibitory factor (MIF), oxidative stress; creatine kinase (CK) and myoglobin; lactate (measurement at T1).<br><br>
- Secondary Outcome Measures
Name Time Method Stool sampling (Art. No. (PZN): 4865079)<br><br>Microbiota examination by means of 16 S amplicon analysis