In vitro human preimplantation embryo development in an adapted culture system based on human uterine fluid composition and uterine pH.
Not yet recruiting
- Conditions
- subfertiliteitinfertilitysubfertility
- Registration Number
- NL-OMON49697
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 700
Inclusion Criteria
Vital thawed human left-over preimplantation embryos, consisting of a minimum
of 5 blastomeres that comprise *50% of the whole embryo, that were donated for
research.
Exclusion Criteria
Of all human left-over day 3 or 4 embryos that were donated for research:
embryos that did not survive the freeze-thawing procedure or embryos that
consist of less than 5 blastomeres and/or are less than 50% vital.
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The primary outcome is the blastocyst formation rate. </p><br>
- Secondary Outcome Measures
Name Time Method <p>Secondary outcomes are embryo quality based on morphological assessment and<br /><br>cell count, embryo metabolism, embryo gene expression, and embryo methylation<br /><br>pattern.</p><br>