ISRCTN21836222CompletedNot Applicable
aser Assisted Hatching before embryo transfer improves the clinical outcome in Vitrified OOcyte Donation cycles: A randomized controlled study
IAKENTRO Advanced Medical Center0 sites182 target enrollmentStarted: January 31, 2017Last updated:
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 182
Study Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Interventional
Eligibility Criteria
- Sex
- Female
Inclusion Criteria
- •Oocyte donor inclusion criteria:
- •1. Up to 32 years old
- •2. Body mass index of less than 30 kg/m2
- •3. Regular menstrual cycles of 25–35 days
- •4. Two normal ovaries based on transvaginal scan findings
- •5. No polycystic ovary syndrome
- •6. No known endometriosis
- •7. No gynecological or medical disorders
- •8. Agreed to donate their oocytes for treatment anonymously and altruistically
- •9. Known fertility and good ovarian response
- •10. Blood sample given for karyotype and screening for previous viral infection (hepatitis B and C, human immunodeficiency virus, syphilis), thalassemia and cystic fibrosis
- •11. A single stimulation cycle was included for each donor
- •Recipient inclusion criteria:
- •1. Up to 50 years old
- •2. No history of endometriosis
- •3. First oocyte donation cycle
- •4. Blood screening for karyotype and previous viral infections (hepatitis B and C, human immunodeficiency virus, syphilis,) thalassemia and cystic fibrosis, for both the recipient and their partners
- •5. Screened for hysterosalpingogram
- •6. Diagnostic hysteroscopy to eliminate cases presenting hydrosalpinx or intrauterine pathology
- •7. Receive a mock transfer in a cycle previous to their donation cycle and if difficulty was encountered a cervical dilatation was performed
- •8. The recipient’s partner has no severe male infertility indication
Exclusion Criteria
- •Vitrified egg donation exclusion criteria:
- •1. When warmed oocytes are less than 9
- •2. When survived oocytes after warming are less than 6
- •Recipient exclusion criteria:
- •1. More than 2 previous failed oocyte donation cycles
- •2. Severe male factor infertility in partner
Investigators
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