Measurement of the effect of mouthwash against COVID-19
- Conditions
- COVID-19 (SARS-CoV-2 infection)Infections and Infestations
- Registration Number
- ISRCTN25647404
- Lead Sponsor
- Cardiff University
- Brief Summary
2022 Preprint results in https://doi.org/10.1101/2022.02.16.22270842 (added 18/02/2022)
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 78
Eligible patients will be approached and recruited from COVID in-patient wards within Cardiff and Vale University Health Board, Betsi Cadwaladr University Health Board, University Hospitals Bristol NHS Foundation Trust and Cwm Taf Morganwg University Health Board. Only patients who are deemed well enough and able to provide informed consent by their local clinical teams will be approached to take part in the study. Specific inclusion criteria are:
1. Adults aged =18 years
2. With positive SARS-CoV-2 carriage by RT-PCR within 14 days
3. Capable of using the mouthwash required by the trial
4. Capacity and capability to give informed consent to take part in the trial
1. Known or suspected intolerance or hypersensitivity to povidone-iodine or other study materials (or closely related compounds) or any of their stated ingredients
2. Known pregnancy, currently breastfeeding or women of childbearing age without effective contraception
3. Current requirement for invasive or non-invasive ventilation; or planned within next 6 hours
4. Known dermatitis herpetiformis (Duhring's disease)
5. Inability to communicate in English or read English
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Viral load of SARS CoV-2 measured by in vitro culture and confirmed by RT-qPCR at 30 minutes
- Secondary Outcome Measures
Name Time Method Viral load of SARS CoV-2 measured by in vitro culture and confirmed by RT-qPCR at baseline and then after 1, 15 and 60 minutes