Different Dialysis Modalities and Diet on Gastrointestinal Biome and Azotaemic Toxins
Recruiting
- Conditions
- Kidney Failure
- Registration Number
- NCT04714853
- Lead Sponsor
- University College, London
- Brief Summary
. This is a prospective observational pilot study to analyse gastrointestinal tract bacterial populations in peritoneal dialysis and haemodialysis patients under the care of the Royal Free Hospital with chronic kidney disease who have been established on regular haemodialysis and peritoneal dialysis treatments in a Royal Free Hospital kidney care centre.
- Detailed Description
Patients, attending for outpatient haemodialysis and peritoneal dialysis to be tested for gastrointestinal tract bacterial population by taking a single mouth swab, and a stool sample. Additional blood sampling, when patients are having blood tests for routine clinical assessment.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria
- Patients age 18 years and older up to 80 years
- Under the care of the Royal Free Hospital with chronic kidney disease and established on regular haemodialysis or peritoneal dialysis.
- Able to provide written informed consent obtained
Exclusion Criteria
- Patients unable to provide written informed consent
- Patients not fulfilling inclusion criteria
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method generation of bacterial phylogenetic trees by identifying different bacteria from stool samples and oral swabs by analysis of bacterial ribosomal 16S 5 years observational
- Secondary Outcome Measures
Name Time Method measure indoxyl sulphate (IS) and p-Cresyl sulfate (PCS) umol/L 8 years observational
Trial Locations
- Locations (1)
Royal Free Hospital
🇬🇧London, United Kingdom